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View Structure Prediction Details

Protein: PTGES2
Organism: Homo sapiens
Length: 377 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PTGES2.

Description E-value Query
Range
Subject
Range
gi|109469545, gi... - gi|27706734|ref|XP_231144.1| PREDICTED: similar to prostaglandin E synthase 2 [Rattus norvegicus], g...
309.0 [0..1] [377..1]
gi|62898772 - gi|62898772|dbj|BAD97240.1| prostaglandin E synthase 2 isoform 1 variant [Homo sapiens]
296.0 [0..1] [377..1]
PGES2_MOUSE - Prostaglandin E synthase 2 OS=Mus musculus GN=Ptges2 PE=1 SV=3
296.0 [0..1] [377..1]
gi|60729631 - gi|60729631|pir||JC7977 membrane-associated prostaglandin E synthase (EC 5.3.99.3) -2 - human
PGES2_MACFA - Prostaglandin E synthase 2 OS=Macaca fascicularis GN=PTGES2 PE=1 SV=1
293.0 [0..1] [377..1]
gi|109112128 - gi|109112128|ref|XP_001091842.1| PREDICTED: similar to prostaglandin E synthase 2 isoform 1 isoform ...
291.0 [0..1] [377..1]
PGES2_DANRE - Prostaglandin E synthase 2 OS=Danio rerio GN=ptges2 PE=2 SV=1
281.0 [0..10] [374..16]

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Predicted Domain #1
Region A:
Residues: [1-98]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPAARVVRA LWPGGCALAW RLGGRPQPLL PTQSRAGFAG AAGGPSPVAA ARKGSPRLLG  60
   61 AAALALGGAL GLYHTARWHL RAQDLHAERS AAQLSLSS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [99-377]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLQLTLYQYK TCPFCSKVRA FLDFHALPYQ VVEVNPVRRA EIKFSSYRKV PILVAQEGES  60
   61 SQQLNDSSVI ISALKTYLVS GQPLEEIITY YPAMKAVNEQ GKEVTEFGNK YWLMLNEKEA 120
  121 QQVYGGKEAR TEEMKWRQWA DDWLVHLISP NVYRTPTEAL ASFDYIVREG KFGAVEGAVA 180
  181 KYMGAAAMYL ISKRLKSRHR LQDNVREDLY EAADKWVAAV GKDRPFMGGQ KPNLADLAVY 240
  241 GVLRVMEGLD AFDDLMQHTH IQPWYLRVER AITEASPAH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.69897
Match: 1z9hA
Description: Microsomal prostaglandin E synthase type-2
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle