YRC Public Data Repository - Protein Structure Prediction

Protein:	VPS33A
Organism:	Homo sapiens
Length:	596 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VPS33A.

Description	E-value	Query Range	Subject Range
gi\|86821578, gi\|... - gi\|86821578\|gb\|AAI05479.1\| Vacuolar protein sorting 33 homolog A (S. cerevisiae) [Bos taurus], gi\|11...	0.0	[1..596]	[1..596]
gi\|73995170 - gi\|73995170\|ref\|XP_534660.2\| PREDICTED: similar to vacuolar protein sorting 33A [Canis familiaris]	0.0	[1..596]	[1..596]
VP33A_RAT - Vacuolar protein sorting-associated protein 33A OS=Rattus norvegicus GN=Vps33a PE=1 SV=1	0.0	[1..596]	[1..597]
VP3A_MOUSE, VP33... - (Q9D2N9) Vacuolar protein sorting 33A, Vacuolar protein sorting-associated protein 33A OS=Mus muscul...	0.0	[1..596]	[1..598]
gi\|50756409 - gi\|50756409\|ref\|XP_415153.1\| PREDICTED: similar to Vacuolar protein sorting 33 homolog A (S. cerevis...	0.0	[1..594]	[1..595]
gi\|114647529, gi... - gi\|114647531\|ref\|XP_001167575.1\| PREDICTED: vacuolar protein sorting 33A isoform 3 [Pan troglodytes]...	0.0	[36..596]	[6..566]
gi\|7321218, gi\|1... - gi\|7321218\|emb\|CAA73264.2\| sec1-like protein [Loligo pealei], gi\|13096246\|pdb\|1FVH\|A Chain A, Crysta...	0.0	[15..592]	[3..586]

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Predicted Domain #1

Region A:
Residues: [1-596]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAHLSYGRV NLNVLREAVR RELREFLDKC AGSKAIVWDE YLTGPFGLIA QYSLLKEHEV  60
   61 EKMFTLKGNR LPAADVKNII FFVRPRLELM DIIAENVLSE DRRGPTRDFH ILFVPRRSLL 120
  121 CEQRLKDLGV LGSFIHREEY SLDLIPFDGD LLSMESEGAF KECYLEGDQT SLYHAAKGLM 180
  181 TLQALYGTIP QIFGKGECAR QVANMMIRMK REFTGSQNSI FPVFDNLLLL DRNVDLLTPL 240
  241 ATQLTYEGLI DEIYGIQNSY VKLPPEKFAP KKQGDGGKDL PTEAKKLQLN SAEELYAEIR 300
  301 DKNFNAVGSV LSKKAKIISA AFEERHNAKT VGEIKQFVSQ LPHMQAARGS LANHTSIAEL 360
  361 IKDVTTSEDF FDKLTVEQEF MSGIDTDKVN NYIEDCIAQK HSLIKVLRLV CLQSVCNSGL 420
  421 KQKVLDYYKR EILQTYGYEH ILTLHNLEKA GLLKPQTGGR NNYPTIRKTL RLWMDDVNEQ 480
  481 NPTDISYVYS GYAPLSVRLA QLLSRPGWRS IEEVLRILPG PHFEERQPLP TGLQKKRQPG 540
  541 ENRVTLIFFL GGVTFAEIAA LRFLSQLEDG GTEYVIATTK LMNGTSWIEA LMEKPF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	159.0
Match:	1epuA
Description:	Neuronal Sec1, NSec1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
SNARE binding	3.42828022195984	bayes_pls_golite062009
binding	2.7837022903231	bayes_pls_golite062009
syntaxin binding	2.11416428645287	bayes_pls_golite062009
protein binding	1.7224010512877	bayes_pls_golite062009
syntaxin-1 binding	0.269372794919901	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: