YRC Public Data Repository - Protein Structure Prediction

Protein:	PANK1
Organism:	Homo sapiens
Length:	598 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PANK1.

Description	E-value	Query Range	Subject Range
gi\|114631728 - gi\|114631728\|ref\|XP_001143095.1\| PREDICTED: pantothenate kinase 1 isoform 3 [Pan troglodytes]	0.0	[1..598]	[1..598]
gi\|109089890 - gi\|109089890\|ref\|XP_001087260.1\| PREDICTED: similar to pantothenate kinase 1 isoform alpha isoform 4...	0.0	[1..598]	[1..598]
gi\|62642196 - gi\|62642196\|ref\|XP_215283.3\| PREDICTED: similar to Pantothenate kinase 1 (Pantothenic acid kinase 1)...	0.0	[41..598]	[3..550]
gi\|76654550 - gi\|76654550\|ref\|XP_616001.2\| PREDICTED: similar to pantothenate kinase 1 isoform alpha [Bos taurus]	0.0	[7..598]	[174..760]
PANK1_MOUSE - Pantothenate kinase 1 OS=Mus musculus GN=Pank1 PE=1 SV=1	0.0	[41..598]	[3..548]
PANK2 - pantothenate kinase 2 (Hallervorden-Spatz syndrome)	0.0	[21..594]	[2..569]

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Predicted Domain #1

Region A:
Residues: [1-235]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKLVGGGGG QDWACSVAGT SLGGEEAAFE VARPGDQGKA GGGSPGWGCA GIPDSAPGAG  60
   61 VLQAGAVGPA RGGQGAEEVG ESAGGGEERR VRHPQAPALR LLNRKPQGGS GEIKTPENDL 120
  121 QRGRLSRGPR TAPPAPGMGD RSGQQERSVP HSPGAPVGTS AAAVNGLLHN GFHPPPVQPP 180
  181 HVCSRGPVGG SDAAPQRLPL LPELQPQPLL PQHDSPAKKC RLRRRMDSGR KNRPP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	7.0
Match:	1y0fA
Description:	No description for 1y0fA was found.

Predicted Domain #2

Region A:
Residues: [236-598]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FPWFGMDIGG TLVKLVYFEP KDITAEEEQE EVENLKSIRK YLTSNTAYGK TGIRDVHLEL  60
   61 KNLTMCGRKG NLHFIRFPSC AMHRFIQMGS EKNFSSLHTT LCATGGGAFK FEEDFRMIAD 120
  121 LQLHKLDELD CLIQGLLYVD SVGFNGKPEC YYFENPTNPE LCQKKPYCLD NPYPMLLVNM 180
  181 GSGVSILAVY SKDNYKRVTG TSLGGGTFLG LCCLLTGCET FEEALEMAAK GDSTNVDKLV 240
  241 KDIYGGDYER FGLQGSAVAS SFGNMMSKEK RDSISKEDLA RATLVTITNN IGSIARMCAL 300
  301 NENIDRVVFV GNFLRINMVS MKLLAYAMDF WSKGQLKALF LEHEGYFGAV GALLELFKMT 360
  361 DDK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	150.0
Match:	2i7nA
Description:	No description for 2i7nA was found.

Predicted functions:

Term	Confidence	Notes
structural constituent of cytoskeleton	2.46121037473545	bayes_pls_golite062009
cytoskeletal protein binding	2.20983242331685	bayes_pls_golite062009
binding	1.54134537534661	bayes_pls_golite062009
pantothenate kinase activity	1.44039088435404	bayes_pls_golite062009
protein binding	1.16405332128302	bayes_pls_golite062009
actin binding	1.03829083423378	bayes_pls_golite062009
structural molecule activity	0.416185949451087	bayes_pls_golite062009
myosin binding	0.31501932970343	bayes_pls_golite062009
catalytic activity	0.296484721581333	bayes_pls_golite062009
kinase activity	0.18855544139935	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.164763891002303	bayes_pls_golite062009
transferase activity	0.105619024604158	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: