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View Structure Prediction Details

Protein: TMLHE
Organism: Homo sapiens
Length: 421 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TMLHE.

Description E-value Query
Range
Subject
Range
TMLH_MOUSE - Trimethyllysine dioxygenase, mitochondrial OS=Mus musculus GN=Tmlhe PE=1 SV=2
0.0 [1..421] [1..421]
gi|48146647 - gi|48146647|emb|CAG33546.1| TMLHE [Homo sapiens]
0.0 [1..421] [1..421]
gi|109132916 - gi|109132916|ref|XP_001099674.1| PREDICTED: trimethyllysine hydroxylase, epsilon isoform 3 [Macaca m...
0.0 [1..421] [1..421]
TMLH_BOVIN - Trimethyllysine dioxygenase, mitochondrial OS=Bos taurus GN=TMLHE PE=2 SV=1
0.0 [1..421] [1..421]
gi|74008874 - gi|74008874|ref|XP_853649.1| PREDICTED: similar to Trimethyllysine dioxygenase, mitochondrial precur...
0.0 [1..421] [1..421]
gi|55250065, gi|... - gi|78187983|ref|NP_596878.2| trimethyllysine hydroxylase, epsilon [Rattus norvegicus], gi|55250065|g...
0.0 [1..421] [1..433]

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Predicted Domain #1
Region A:
Residues: [1-140]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWYHRLSHLH SRLQDLLKGG VIYPALPQPN FKSLLPLAVH WHHTASKSLT CAWQQHEDHF  60
   61 ELKYANTVMR FDYVWLRDHC RSASCYNSKT HQRSLDTASV DLCIKPKTIR LDETTLFFTW 120
  121 PDGHVTKYDL NWLVKNSYEG 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [141-421]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QKQKVIQPRI LWNAEIYQQA QVPSVDCQSF LETNEGLKKF LQNFLLYGIA FVENVPPTQE  60
   61 HTEKLAERIS LIRETIYGRM WYFTSDFSRG DTAYTKLALD RHTDTTYFQE PCGIQVFHCL 120
  121 KHEGTGGRTL LVDGFYAAEQ VLQKAPEEFE LLSKVPLKHE YIEDVGECHN HMIGIGPVLN 180
  181 IYPWNKELYL IRYNNYDRAV INTVPYDVVH RWYTAHRTLT IELRRPENEF WVKLKPGRVL 240
  241 FIDNWRVLHG RECFTGYRQL CGCYLTRDDV LNTARLLGLQ A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.154902
Match: 1gqwA
Description: Taurine/alpha-ketoglutarate dioxygenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
damaged DNA binding 2.1600632791412 bayes_pls_golite062009
oxidoreductase activity 2.14660717798066 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors 1.96457406152694 bayes_pls_golite062009
binding 0.997838210709106 bayes_pls_golite062009
catalytic activity 0.921320409505 bayes_pls_golite062009
nucleic acid binding 0.195303464765705 bayes_pls_golite062009
DNA binding 0.119653205743915 bayes_pls_golite062009
protein binding 0.0481711987500598 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle