YRC Public Data Repository - Protein Structure Prediction

Protein:	CLEC4M
Organism:	Homo sapiens
Length:	399 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CLEC4M.

Description	E-value	Query Range	Subject Range
CLC4M_HYLLA - C-type lectin domain family 4 member M OS=Hylobates lar GN=CLEC4M PE=3 SV=1	2.0E-44	[1..399]	[1..399]
CLC4M_NOMCO - C-type lectin domain family 4 member M OS=Nomascus concolor GN=CLEC4M PE=3 SV=1	1.0E-43	[1..399]	[1..399]
gi\|12084797 - gi\|12084797\|gb\|AAG13848.2\| probable mannose binding C-type lectin DC-SIGNR [Homo sapiens]	2.0E-43	[1..399]	[1..399]
CLC4M_SYMSY - C-type lectin domain family 4 member M OS=Symphalangus syndactylus GN=CLEC4M PE=3 SV=1	4.0E-41	[1..399]	[1..422]
CLC4M_GORGO - C-type lectin domain family 4 member M OS=Gorilla gorilla gorilla GN=CLEC4M PE=3 SV=1 gi\|27356845 - gi\|27356845\|gb\|AAL89534.1\| putative CD209L1 protein [Gorilla gorilla]	3.0E-40	[1..399]	[1..376]
gi\|15420782 - gi\|15420782\|gb\|AAK97458.1\|AF391085_1 dendritic cell-specific ICAM-3 grabbing non-integrin [Pan trogl...	3.0E-40	[1..399]	[1..388]

Back

Predicted Domain #1

Region A:
Residues: [1-172]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSKEPRVQ QLGLLEEDPT TSGIRLFPRD FQFQQIHGHK SSTGCLGHGA LVLQLLSFML  60
   61 LAGVLVAILV QVSKVPSSLS QEQSEQDAIY QNLTQLKAAV GELSEKSKLQ EIYQELTQLK 120
  121 AAVGELPEKS KLQEIYQELT RLKAAVGELP EKSKLQEIYQ ELTRLKAAVG EL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	18.221849
Match:	2o6qA
Description:	No description for 2o6qA was found.

Predicted Domain #2

Region A:
Residues: [173-262]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEKSKLQEIY QELTRLKAAV GELPEKSKLQ EIYQELTELK AAVGELPEKS KLQEIYQELT  60
   61 QLKAAVGELP DQSKQQQIYQ ELTDLKTAFE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.941	a.24.3	Cytochromes
View	Download	0.985	a.24.4	Hemerythrin
View	Download	0.947	a.24.7	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View	Download	0.916	a.7.6	Ribosomal protein S20
View	Download	0.924	a.24.3	Cytochromes

Predicted Domain #3

Region A:
Residues: [263-399]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLCRHCPKDW TFFQGNCYFM SNSQRNWHDS VTACQEVRAQ LVVIKTAEEQ NFLQLQTSRS  60
   61 NRFSWMGLSD LNQEGTWQWV DGSPLSPSFQ RYWNSGEPNN SGNEDCAEFS GSGWNDNRCD 120
  121 VDNYWICKKP AACFRDE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	26.09691
Match:	1sl6A
Description:	Crystal Structure of a fragment of DC-SIGNR (containg the carbohydrate recognition domain and two repeats of the neck) complexed with Lewis-x.
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits