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View Structure Prediction Details

Protein: MRPL46
Organism: Homo sapiens
Length: 279 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MRPL46.

Description E-value Query
Range
Subject
Range
gi|114658725 - gi|114658725|ref|XP_510572.2| PREDICTED: mitochondrial ribosomal protein L46 isoform 2 [Pan troglody...
0.0 [1..279] [1..279]
RM46_RAT - 39S ribosomal protein L46, mitochondrial OS=Rattus norvegicus GN=Mrpl46 PE=2 SV=1
0.0 [1..279] [1..277]
gi|109082282 - gi|109082282|ref|XP_001088970.1| PREDICTED: similar to mitochondrial ribosomal protein L46 isoform 2...
0.0 [1..279] [1..279]
RM46_PONPY - 39S ribosomal protein L46, mitochondrial precursor - Pongo pygmaeus (Orangutan)
RM46_PONAB - 39S ribosomal protein L46, mitochondrial OS=Pongo abelii GN=MRPL46 PE=2 SV=1
0.0 [1..279] [1..279]
gi|73951430 - gi|73951430|ref|XP_536185.2| PREDICTED: similar to mitochondrial ribosomal protein L46 [Canis famili...
0.0 [1..279] [1..280]
RM46_MOUSE - 39S ribosomal protein L46, mitochondrial OS=Mus musculus GN=Mrpl46 PE=1 SV=1
0.0 [1..278] [1..276]
RM46_BOVIN - 39S ribosomal protein L46, mitochondrial OS=Bos taurus GN=MRPL46 PE=2 SV=1
4.0E-95 [1..279] [1..277]
gi|11275665 - gi|11275665|gb|AAG33698.1| P2ECSL [Homo sapiens]
1.0E-81 [70..279] [1..210]
gi|116127281, gi... - gi|118788447|ref|XP_316723.3| AGAP006684-PA [Anopheles gambiae str. PEST], gi|116127281|gb|EAA11413....
AGAP006684-PA - mRpL46: 39S ribosomal protein L46, mitochondrial|protein_coding|2L:36681148:36682028:-1|gene:AGAP006...
3.0E-78 [27..276] [16..270]

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Predicted Domain #1
Region A:
Residues: [1-137]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAPVRRTLL GVAGGWRRFE RLWAGSLSSR SLALAAAPSS NGSPWRLLGA LCLQRPPVVS  60
   61 KPLTPLQEEM ASLLQQIEIE RSLYSDHELR ALDENQRLAK KKADLHDEED EQDILLAQDL 120
  121 EDMWEQKFLQ FKLGARI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.549 0.937 ribonucleoprotein complex d.58.7 RNA-binding domain, RBD

Predicted Domain #2
Region A:
Residues: [138-279]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TEADEKNDRT SLNRKLDRNL VLLVREKFGD QDVWILPQAE WQPGETLRGT AERTLATLSE  60
   61 NNMEAKFLGN APCGHYTFKF PQAMRTESNL GAKVFFFKAL LLTGDFSQAG NKGHHVWVTK 120
  121 DELGDYLKPK YLAQVRRFVS DL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.22
Match: 2azwA
Description: Crystal structure of the MutT/nudix family protein from Enterococcus faecalis
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle