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View Structure Prediction Details

Protein: EMD
Organism: Homo sapiens
Length: 254 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EMD.

Description E-value Query
Range
Subject
Range
gi|109132796 - gi|109132796|ref|XP_001090376.1| PREDICTED: emerin (Emery-Dreifuss muscular dystrophy) [Macaca mulat...
2.0E-85 [1..254] [1..254]
gi|61372645, gi|... - gi|61372651|gb|AAX43883.1| emerin [synthetic construct], gi|61372645|gb|AAX43882.1| emerin [syntheti...
1.0E-82 [1..254] [1..254]
EMD_MOUSE - Emerin OS=Mus musculus GN=Emd PE=1 SV=1
3.0E-82 [1..254] [1..255]
EMD_RAT - Emerin OS=Rattus norvegicus GN=Emd PE=1 SV=1
5.0E-78 [1..254] [1..256]
gi|42733600, gi|... - gi|42733600|ref|NP_976237.1| emerin [Bos taurus], gi|37781186|gb|AAO60066.1| emerin [Bos taurus]
4.0E-77 [1..254] [1..257]
gi|57284205, gi|... - gi|57284205|emb|CAI43229.1| emerin [Homo sapiens], gi|119593149|gb|EAW72743.1| emerin (Emery-Dreifus...
1.0E-69 [1..254] [1..219]

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Predicted Domain #1
Region A:
Residues: [1-74]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDNYADLSDT ELTTLLRRYN IPHGPVVGST RRLYEKKIFE YETQRRRLSP PSSSAASSYS  60
   61 FSDLNSTRGD ADMY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.522879
Match: 1jeiA
Description: Inner nuclear membrane protein emerin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
lamin binding 4.39382764264433 bayes_pls_golite062009
binding 2.48575835933363 bayes_pls_golite062009
protein binding 1.25020901551294 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [75-127]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLPKKEDALL YQSKGYNDDY YEESYFTTRT YGEPESAGPS RAVRQSVTSF PDA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [128-254]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DAFHHQVHDD DLLSSSEEEC KDRERPMYGR DSAYQSITHY RPVSASRSSL DLSYYPTSSS  60
   61 TSFMSSSSSS SSWLTRRAIR PENRAPGAGL GQDRQVPLWG QLLLFLVFVI VLFFIYHFMQ 120
  121 AEEGNPF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle