YRC Public Data Repository - Protein Structure Prediction

Protein:	CTNNB1
Organism:	Homo sapiens
Length:	781 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CTNNB1.

Description	E-value	Query Range	Subject Range
gi\|156619752 - gi\|156619752\|gb\|ABU88472.1\| beta-catenin [Anser anser] gi\|2511456, gi\|4... - gi\|46048792\|ref\|NP_990412.1\| catenin (cadherin-associated protein), beta 1, 88kDa [Gallus gallus], g...	0.0	[1..781]	[1..781]
gi\|82547204, gi\|... - gi\|82547204\|gb\|ABB82357.1\| beta catenin 1 [Equus caballus], gi\|170287751\|ref\|NP_001116234.1\| catenin... gi\|47523792, gi\|... - gi\|47523792\|ref\|NP_999532.1\| catenin (cadherin-associated protein), beta 1, 88kDa [Sus scrofa], gi\|1... CTNB1_BOVIN - Catenin beta-1 OS=Bos taurus GN=CTNNB1 PE=1 SV=1 CTNB1_CANLF - Catenin beta-1 OS=Canis lupus familiaris GN=CTNNB1 PE=1 SV=1	0.0	[1..781]	[1..781]
CTNB1_RAT - Catenin beta-1 OS=Rattus norvegicus GN=Ctnnb1 PE=1 SV=1	0.0	[1..781]	[1..781]
CTNB1_MOUSE - Catenin beta-1 OS=Mus musculus GN=Ctnnb1 PE=1 SV=1 tr\|G3H996\|G3H996... - Catenin beta-1 OS=Cricetulus griseus GN=I79_006962 PE=4 SV=1 gi\|149018207, gi... - gi\|15149346\|gb\|AAK85253.1\| beta-catenin [Rattus norvegicus], gi\|149018209\|gb\|EDL76850.1\| catenin (ca...	0.0	[1..781]	[1..781]
gi\|224045536 - gi\|224045536\|ref\|XP_002199072.1\| PREDICTED: catenin (cadherin-associated protein), beta 1, 88kDa [Ta... gi\|205318885 - gi\|205318885\|gb\|ACI02435.1\| beta-catenin [Anas platyrhynchos] gi\|542154084\|ref... - PREDICTED: catenin beta-1 [Zonotrichia albicollis] gi\|56377802 - gi\|56377802\|dbj\|BAD74125.1\| beta-catenin homologue [Pelodiscus sinensis]	0.0	[1..781]	[1..781]
gi\|34740265 - gi\|34740265\|dbj\|BAC87743.1\| beta-catenin [Meriones unguiculatus]	0.0	[1..781]	[1..781]
gi\|73989822 - gi\|73989822\|ref\|XP_861079.1\| PREDICTED: similar to catenin (cadherin-associated protein), beta 1, 88...	0.0	[1..781]	[1..786]

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Predicted Domain #1

Region A:
Residues: [1-117]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG NPEEEDVDTS  60
   61 QVLYEWEQGF SQSFTQEQVA DIDGQYAMTR AQRVRAAMFP ETLDEGMQIP STQFDAA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	68.69897
Match:	1wa5B
Description:	Crystal structure of the exportin Cse1p complexed with its cargo ( Kap60p) and RanGTP
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [118-532]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HPTNVQRLAE PSQMLKHAVV NLINYQDDAE LATRAIPELT KLLNDEDQVV VNKAAVMVHQ  60
   61 LSKKEASRHA IMRSPQMVSA IVRTMQNTND VETARCTAGT LHNLSHHREG LLAIFKSGGI 120
  121 PALVKMLGSP VDSVLFYAIT TLHNLLLHQE GAKMAVRLAG GLQKMVALLN KTNVKFLAIT 180
  181 TDCLQILAYG NQESKLIILA SGGPQALVNI MRTYTYEKLL WTTSRVLKVL SVCSSNKPAI 240
  241 VEAGGMQALG LHLTDPSQRL VQNCLWTLRN LSDAATKQEG MEGLLGTLVQ LLGSDDINVV 300
  301 TCAAGILSNL TCNNYKNKMM VCQVGGIEAL VRTVLRAGDR EDITEPAICA LRHLTSRHQE 360
  361 AEMAQNAVRL HYGLPVVVKL LHPPSHWPLI KATVGLIRNL ALCPANHAPL REQGA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	16.39794
Match:	1w63A
Description:	AP1 clathrin adaptor core
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [533-603]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPRLVQLLVR AHQDTQRRTS MGGTQQQFVE GVRMEEIVEG CTGALHILAR DVHNRIVIRG  60
   61 LNTIPLFVQL L

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.75
Match:	2gl7A
Description:	No description for 2gl7A was found.

Predicted Domain #4

Region A:
Residues: [604-692]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YSPIENIQRV AAGVLCELAQ DKEAAEAIEA EGATAPLTEL LHSRNEGVAT YAAAVLFRMS  60
   61 EDKPQDYKKR LSVELTSSLF RTEPMAWNE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	88.0
Match:	2gl7A
Description:	No description for 2gl7A was found.

Predicted Domain #5

Region A:
Residues: [693-781]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TADLGLDIGA QGEPLGYRQD DPSYRSFHSG GYGQDALGMD PMMEHEMGGH HPGADYPVDG  60
   61 LPDLGHAQDL MDGLPPGDSN QLAWFDTDL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.311	0.045	endoderm formation	a.52.1	Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View	Download	0.308	0.037	endoderm formation	a.4.6	C-terminal effector domain of the bipartite response regulators
View	Download	0.260	0.012	endoderm formation	a.101.1	Uteroglobin-like
View	Download	0.411	0.005	endoderm formation	a.13.1	alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View	Download	0.276	N/A	N/A	a.76.1	Iron-dependent represor protein, dimerization domain

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits