YRC Public Data Repository - Protein Structure Prediction

Protein:	IDH2
Organism:	Homo sapiens
Length:	452 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IDH2.

Description	E-value	Query Range	Subject Range
gi\|114658862 - gi\|114658862\|ref\|XP_510589.2\| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial isoform 4...	0.0	[1..452]	[1..452]
IDHP_MOUSE - Isocitrate dehydrogenase [NADP], mitochondrial OS=Mus musculus GN=Idh2 PE=1 SV=3	0.0	[1..452]	[1..452]
IDHP_RAT - Isocitrate dehydrogenase [NADP], mitochondrial OS=Rattus norvegicus GN=Idh2 PE=1 SV=2	0.0	[1..452]	[1..452]
gi\|62897391 - gi\|62897391\|dbj\|BAD96636.1\| isocitrate dehydrogenase 2 (NADP+), mitochondrial precursor variant [Hom...	0.0	[1..452]	[1..452]
IDHP_MACFA - Isocitrate dehydrogenase [NADP], mitochondrial OS=Macaca fascicularis GN=IDH2 PE=2 SV=1 gi\|109082346 - gi\|109082346\|ref\|XP_001095686.1\| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial [Macac...	0.0	[1..452]	[1..452]
IDHP_BOVIN - (Q04467) Isocitrate dehydrogenase [NADP], mitochondrial precursor (EC 1.1.1.42) (Oxalosuccinate deca...	0.0	[1..452]	[1..452]

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Predicted Domain #1

Region A:
Residues: [1-452]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGYLRVVRS LCRASGSRPA WAPAALTAPT SQEQPRRHYA DKRIKVAKPV VEMDGDEMTR  60
   61 IIWQFIKEKL ILPHVDIQLK YFDLGLPNRD QTDDQVTIDS ALATQKYSVA VKCATITPDE 120
  121 ARVEEFKLKK MWKSPNGTIR NILGGTVFRE PIICKNIPRL VPGWTKPITI GRHAHGDQYK 180
  181 ATDFVADRAG TFKMVFTPKD GSGVKEWEVY NFPAGGVGMG MYNTDESISG FAHSCFQYAI 240
  241 QKKWPLYMST KNTILKAYDG RFKDIFQEIF DKHYKTDFDK NKIWYEHRLI DDMVAQVLKS 300
  301 SGGFVWACKN YDGDVQSDIL AQGFGSLGLM TSVLVCPDGK TIEAEAAHGT VTRHYREHQK 360
  361 GRPTSTNPIA SIFAWTRGLE HRGKLDGNQD LIRFAQMLEK VCVETVESGA MTKDLAGCIH 420
  421 GLSNVKLNEH FLNTTDFLDT IKSNLDRALG RQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	139.0
Match:	1lwdA
Description:	NADP-dependent isocitrate dehydrogenase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits