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View Structure Prediction Details

Protein: CSF2
Organism: Homo sapiens
Length: 144 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CSF2.

Description E-value Query
Range		 Subject
Range
CSF2_CEREL - Granulocyte-macrophage colony-stimulating factor OS=Cervus elaphus GN=CSF2 PE=2 SV=1
 1.0E-76 [1..144] [1..144]
CSF2_SHEEP - Granulocyte-macrophage colony-stimulating factor OS=Ovis aries GN=CSF2 PE=2 SV=1
 5.0E-76 [1..144] [1..144]
gi|62825818 - gi|62825818|gb|AAY16326.1| granulocyte-macrophage colony stimulating factor [Capra hircus]
 2.0E-75 [1..144] [1..144]
gi|181146, gi|30... - gi|3002476|gb|AAC08707.1| CSF1 [Homo sapiens], gi|181146|gb|AAA52121.1| colony-stimulating factor [H...
 3.0E-74 [1..144] [1..144]
gi|74136451, gi|... - gi|74136451|ref|NP_001028121.1| granulocyte-macrophage colony-stimulating factor [Macaca mulatta], g...
 6.0E-74 [1..144] [1..144]
gi|114601536 - gi|114601536|ref|XP_527005.2| PREDICTED: hypothetical protein [Pan troglodytes]
 8.0E-74 [1..144] [1..144]
CSF2_CHLAE - Granulocyte-macrophage colony-stimulating factor OS=Chlorocebus aethiops GN=CSF2 PE=2 SV=1
 1.0E-73 [1..144] [1..144]
gi|22208938 - gi|22208938|gb|AAL41017.2|AF448481_1 granulocyte-macrophage colony-stimulating factor [Equus caballu...
 2.0E-73 [1..144] [1..144]

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Predicted Domain #1
Region A:
Residues: [1-144] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWLQSLLLLG TVACSISAPA RSPSPSTQPW EHVNAIQEAR RLLNLSRDTA AEMNETVEVI  60
   61 SEMFDLQEPT CLQTRLELYK QGLRGSLTKL KGPLTMMASH YKQHCPPTPE TSCATQIITF 120
  121 ESFKENLKDF LLVIPFDCWE PVQE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 66.0
Match: 1csgA
Description: Granulocyte-macrophage colony-stimulating factor (GM-CSF)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytokine receptor binding 6.47223189691244 bayes_pls_golite062009
receptor binding 5.3304255990112 bayes_pls_golite062009
cytokine activity 5.22856893358132 bayes_pls_golite062009
growth factor activity 4.92105782010612 bayes_pls_golite062009
protein binding 3.26483713001551 bayes_pls_golite062009
growth hormone activity 2.71439518801599 bayes_pls_golite062009
binding 2.48265117231403 bayes_pls_golite062009
prolactin receptor binding 2.45721634350294 bayes_pls_golite062009
interleukin-6 receptor binding 2.37535614986843 bayes_pls_golite062009
hormone activity 2.25587306265428 bayes_pls_golite062009
interleukin-27 binding 1.83998174953013 bayes_pls_golite062009
ciliary neurotrophic factor receptor binding 1.79326213321183 bayes_pls_golite062009
macrophage colony stimulating factor receptor binding 1.17163557856578 bayes_pls_golite062009
erythropoietin receptor binding 0.77580300541347 bayes_pls_golite062009
interleukin-12 binding 0.41824625672928 bayes_pls_golite062009
interleukin-3 receptor binding 0.264629367313661 bayes_pls_golite062009
catalytic activity 0.246169290135575 bayes_pls_golite062009
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