YRC Public Data Repository - Protein Structure Prediction

Protein:	PES1
Organism:	Homo sapiens
Length:	588 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PES1.

Description	E-value	Query Range	Subject Range
gi\|114685878 - gi\|114685878\|ref\|XP_515076.2\| PREDICTED: pescadillo homolog 1, containing BRCT domain isoform 3 [Pan...	718.0	[0..1]	[561..1]
gi\|60654483 - gi\|60654483\|gb\|AAX29932.1\| pescadillo-like 1 containing BRCT domain [synthetic construct]	710.0	[0..1]	[588..1]
PESC_RAT - Pescadillo homolog OS=Rattus norvegicus GN=Pes1 PE=2 SV=1	705.0	[0..1]	[587..1]
gi\|55715986 - gb\|AAH86254.1\| Unknown (protein for MGC:98773) [Xenopus laevis] PESC_MOUSE - Pescadillo homolog OS=Mus musculus GN=Pes1 PE=1 SV=1	705.0	[0..1]	[587..1]
HGNC:8848\|MIM:60... - homolog 1, containing BRCT domain (zebrafish) gi\|47678609 - gi\|47678609\|emb\|CAG30425.1\| PES1 [Homo sapiens] gi\|109451418, gi... - gi\|109452014\|emb\|CAK54869.1\| PES1 [synthetic construct], gi\|109451418\|emb\|CAK54570.1\| PES1 [syntheti...	701.0	[0..1]	[588..1]
PESC_XENLA - Pescadillo homolog OS=Xenopus laevis GN=pes1 PE=2 SV=1	685.0	[0..1]	[580..1]
gi\|73995433 - gi\|73995433\|ref\|XP_543480.2\| PREDICTED: similar to pescadillo homolog 1, containing BRCT domain [Can...	684.0	[0..1]	[584..1]

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Predicted Domain #1

Region A:
Residues: [1-180]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGLEKKKYE RGSATNYITR NKARKKLQLS LADFRRLCIL KGIYPHEPKH KKKVNKGSTA  60
   61 ARTFYLIKDI RFLLHEPIVN KFREYKVFVR KLRKAYGKSE WNTVERLKDN KPNYKLDHII 120
  121 KERYPTFIDA LRDLDDALSM CFLFSTFPRT GKCHVQTIQL CRRLTVEFMH YIIAARALRK 180
  181

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [181-250]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VFLSIKGIYY QAEVLGQPIV WITPYAFSHD HPTDVDYRVM ATFTEFYTTL LGFVNFRLYQ  60
   61 LLNLHYPPKL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [251-588]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGQAQAEAKA GEGTYALDSE SCMEKLAALS ASLARVVVPA TEEEAEVDEF PTDGEMSAQE  60
   61 EDRRKELEAQ EKHKKLFEGL KFFLNREVPR EALAFIIRSF GGEVSWDKSL CIGATYDVTD 120
  121 SRITHQIVDR PGQQTSVIGR CYVQPQWVFD SVNARLLLPV AEYFSGVQLP PHLSPFVTEK 180
  181 EGDYVPPEKL KLLALQRGED PGNLNESEEE EEEDDNNEGD GDEEGENEEE EEDAEAGSEK 240
  241 EEEARLAALE EQRMEGKKPR VMAGTLKLED KQRLAQEEES EAKRLAIMMM KKREKYLYQK 300
  301 IMFGKRRKIR EANKLAEKRK AHDEAVRSEK KAKKARPE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	18.69897
Match:	1i84S
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits