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View Structure Prediction Details

Protein: DAND5
Organism: Homo sapiens
Length: 189 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DAND5.

Description E-value Query
Range
Subject
Range
gi|114675666 - gi|114675666|ref|XP_001170597.1| PREDICTED: hypothetical protein [Pan troglodytes]
7.0E-55 [1..189] [1..189]
DAND5_MOUSE - DAN domain family member 5 OS=Mus musculus GN=Dand5 PE=2 SV=1
3.0E-47 [1..188] [1..184]
gi|109111501 - gi|109111501|ref|XP_001110846.1| PREDICTED: similar to cerberus 1 [Macaca mulatta]
3.0E-47 [23..189] [89..245]
gi|47479501 - gi|47479501|gb|AAH69491.1| Cerberus 1 [Homo sapiens]
1.0E-46 [23..189] [89..245]

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Predicted Domain #1
Region A:
Residues: [1-189]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLGQLSTLL CLLSGALPTG SGRPEPQSPR PQSWAAANQT WALGPGALPP LVPASALGSW  60
   61 KAFLGLQKAR QLGMGRLQRG QDEVAAVTLP LNPQEVIQGM CKAVPFVQVF SRPGCSAIRL 120
  121 RNHLCFGHCS SLYIPGSDPT PLVLCNSCMP ARKRWAPVVL WCLTGSSASR RRVKISTMLI 180
  181 EGCHCSPKA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.06
Match: 1m4uA
Description: Noggin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor serine/threonine kinase binding 2.61683486163082 bayes_pls_golite062009
receptor binding 2.47511349613439 bayes_pls_golite062009
transforming growth factor beta receptor binding 2.39976050758366 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 2.39976050758366 bayes_pls_golite062009
binding 2.25218361714745 bayes_pls_golite062009
protein binding 1.92369246162193 bayes_pls_golite062009
growth factor activity 1.4973683227451 bayes_pls_golite062009
protein dimerization activity 0.878571015119069 bayes_pls_golite062009
protein homodimerization activity 0.678907830578514 bayes_pls_golite062009
identical protein binding 0.534614201318531 bayes_pls_golite062009
growth factor binding 0.4409182799008 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle