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View Structure Prediction Details

Protein: CRYAA
Organism: Homo sapiens
Length: 173 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CRYAA.

Description E-value Query
Range		 Subject
Range
CRYAA_LOXAF - Alpha-crystallin A chain OS=Loxodonta africana GN=CRYAA PE=1 SV=1
 3.0E-46 [1..173] [1..173]
CRYAA_PROCA - Alpha-crystallin A chain OS=Procavia capensis GN=CRYAA PE=1 SV=1
 9.0E-46 [1..173] [1..173]
CRYAA_PEDCA - Alpha-crystallin A chain OS=Pedetes capensis GN=CRYAA PE=1 SV=1
CRYAA_CAVPO - Alpha-crystallin A chain OS=Cavia porcellus GN=CRYAA PE=1 SV=1
 1.0E-45 [1..173] [1..173]
CRYAA_OCHPR - Alpha-crystallin A chain OS=Ochotona princeps GN=CRYAA PE=1 SV=1
 2.0E-45 [1..173] [1..173]
CRAA_MOUSE - (P02490) Alpha crystallin A chain, major component
CRYAA_MERUN - Alpha-crystallin A chain OS=Meriones unguiculatus GN=CRYAA PE=1 SV=1
gi|71459 - pir||CYHYA alpha-crystallin chain A - golden hamster (tentative sequence)
gi|229522, gi|14... - pir||CYRTA alpha-crystallin chain A - rat, gi|229522|prf||751000H crystallin alphaA2, gi|19526477|r...
tr|G3HLE9|G3HLE9... - Alpha-crystallin A chain OS=Cricetulus griseus GN=I79_011537 PE=3 SV=1
CRYAA_TUPGL - Alpha-crystallin A chain OS=Tupaia glis GN=CRYAA PE=1 SV=1
 2.0E-45 [1..173] [1..173]
CRYAA_ARTJA - Alpha-crystallin A chain OS=Artibeus jamaicensis GN=CRYAA PE=1 SV=1
 2.0E-45 [1..173] [1..173]
CRYAA_RABIT - Alpha-crystallin A chain OS=Oryctolagus cuniculus GN=CRYAA PE=1 SV=3
 2.0E-45 [1..173] [1..173]
CRYAA_MELUS - Alpha-crystallin A chain OS=Melursus ursinus GN=CRYAA PE=1 SV=1
 3.0E-45 [1..173] [1..173]
CRYAA_EULFU - Alpha-crystallin A chain OS=Eulemur fulvus fulvus GN=CRYAA PE=1 SV=1
 3.0E-45 [1..173] [1..173]
CRYAA_BALAC - Alpha-crystallin A chain OS=Balaenoptera acutorostrata GN=CRYAA PE=1 SV=1
 4.0E-45 [1..173] [1..173]

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Predicted Domain #1
Region A:
Residues: [1-173] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVTIQHPWF KRTLGPFYPS RLFDQFFGEG LFEYDLLPFL SSTISPYYRQ SLFRTVLDSG  60
   61 ISEVRSDRDK FVIFLDVKHF SPEDLTVKVQ DDFVEIHGKH NERQDDHGYI SREFHRRYRL 120
  121 PSNVDQSALS CSLSADGMLT FCGPKIQTGL DATHAERAIP VSREEKPTSA PSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.221849
Match: 1gmeA
Description: Small heat shock protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.9759530321894 bayes_pls_golite062009
protein binding 0.743263427072441 bayes_pls_golite062009
unfolded protein binding 0.540503020005284 bayes_pls_golite062009
catalytic activity 0.260308151913118 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle