YRC Public Data Repository - Protein Structure Prediction

Protein:	ITGB5
Organism:	Homo sapiens
Length:	799 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ITGB5.

Description	E-value	Query Range	Subject Range
gi\|114588810 - gi\|114588810\|ref\|XP_516706.2\| PREDICTED: hypothetical protein [Pan troglodytes]	0.0	[1..799]	[101..899]
gi\|113415205 - gi\|113415205\|ref\|XP_001129224.1\| PREDICTED: similar to Integrin beta-5 precursor [Homo sapiens]	0.0	[20..799]	[179..958]
gi\|116283905, gi... - gi\|74148728\|dbj\|BAE24299.1\| unnamed protein product [Mus musculus], gi\|34849604\|gb\|AAH58246.1\| Itgb5...	0.0	[1..799]	[1..799]
gi\|60653757, gi\|... - gi\|60653759\|gb\|AAX29573.1\| integrin beta 5 [synthetic construct], gi\|60653757\|gb\|AAX29572.1\| integri...	0.0	[1..799]	[1..799]
gi\|158517933, gi... - gi\|158517933\|ref\|NP_671480.2\| integrin, beta 5 [Rattus norvegicus], gi\|109494417\|ref\|XP_001064622.1\|...	0.0	[1..799]	[1..799]
gi\|18656905, gi\|... - gi\|27807227\|ref\|NP_777104.1\| integrin, beta 5 [Bos taurus], gi\|18656905\|gb\|AAL78038.1\|AF468059_1 int...	0.0	[1..799]	[1..800]

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Predicted Domain #1

Region A:
Residues: [1-737]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRAPAPLYA CLLGLCALLP RLAGLNICTS GSATSCEECL LIHPKCAWCS KEDFGSPRSI  60
   61 TSRCDLRANL VKNGCGGEIE SPASSFHVLR SLPLSSKGSG SAGWDVIQMT PQEIAVNLRP 120
  121 GDKTTFQLQV RQVEDYPVDL YYLMDLSLSM KDDLDNIRSL GTKLAEEMRK LTSNFRLGFG 180
  181 SFVDKDISPF SYTAPRYQTN PCIGYKLFPN CVPSFGFRHL LPLTDRVDSF NEEVRKQRVS 240
  241 RNRDAPEGGF DAVLQAAVCK EKIGWRKDAL HLLVFTTDDV PHIALDGKLG GLVQPHDGQC 300
  301 HLNEANEYTA SNQMDYPSLA LLGEKLAENN INLIFAVTKN HYMLYKNFTA LIPGTTVEIL 360
  361 DGDSKNIIQL IINAYNSIRS KVELSVWDQP EDLNLFFTAT CQDGVSYPGQ RKCEGLKIGD 420
  421 TASFEVSLEA RSCPSRHTEH VFALRPVGFR DSLEVGVTYN CTCGCSVGLE PNSARCNGSG 480
  481 TYVCGLCECS PGYLGTRCEC QDGENQSVYQ NLCREAEGKP LCSGRGDCSC NQCSCFESEF 540
  541 GKIYGPFCEC DNFSCARNKG VLCSGHGECH CGECKCHAGY IGDNCNCSTD ISTCRGRDGQ 600
  601 ICSERGHCLC GQCQCTEPGA FGEMCEKCPT CPDACSTKRD CVECLLLHSG KPDNQTCHSL 660
  661 CRDEVITWVD TIVKDDQEAV LCFYKTAKDC VMMFTYVELP SGKSNLTVLR EPECGNTPNA 720
  721 MTILLAVVGS ILLVGLA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	114.0
Match:	1jv2B
Description:	Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [738-799]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLAIWKLLVT IHDRREFAKF QSERSRARYE MASNPLYRKP ISTHTVDFTF NKFNKSYNGT  60
   61 VD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	9.69897
Match:	1s4xA
Description:	NMR Structure of the integrin B3 cytoplasmic domain in DPC micelles
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits