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View Structure Prediction Details

Protein: IAH1
Organism: Homo sapiens
Length: 248 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IAH1.

Description E-value Query
Range		 Subject
Range
gi|109101965 - gi|109101965|ref|XP_001084501.1| PREDICTED: hypothetical protein isoform 2 [Macaca mulatta]
 4.0E-60 [1..248] [1..248]
IAH1_RAT - Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Rattus norvegicus GN=Iah1 PE=2 SV=2
 2.0E-59 [1..248] [1..249]
IAH1_MOUSE - Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Mus musculus GN=Iah1 PE=1 SV=1
 3.0E-58 [1..248] [1..249]
gi|73980321 - gi|73980321|ref|XP_852049.1| PREDICTED: hypothetical protein XP_846956 [Canis familiaris]
 2.0E-57 [1..248] [1..249]
IAH1_BOVIN - Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Bos taurus GN=IAH1 PE=2 SV=1
 2.0E-56 [1..248] [1..249]
gi|114576030 - gi|114576030|ref|XP_001155356.1| PREDICTED: hypothetical protein isoform 1 [Pan troglodytes]
gi|119621391 - gi|119621391|gb|EAX00986.1| hCG1685787, isoform CRA_c [Homo sapiens]
 8.0E-51 [26..248] [1..223]
gi|50745011 - gi|50745011|ref|XP_419943.1| PREDICTED: similar to hypothetical protein 4833421E05Rik [Gallus gallus...
 5.0E-50 [1..244] [67..310]
gi|116283448 - gi|116283448|gb|AAH19061.1| IAH1 protein [Homo sapiens]
 8.0E-46 [45..248] [37..240]

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Predicted Domain #1
Region A:
Residues: [1-248] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALCEAAGCG SALLWPRLLL FGDSITQFSF QQGGWGASLA DRLVRKCDVL NRGFSGYNTR  60
   61 WAKIILPRLI RKGNSLDIPV AVTIFFGAND SALKDENPKQ HIPLEEYAAN LKSMVQYLKS 120
  121 VDIPENRVIL ITPTPLCETA WEEQCIIQGC KLNRLNSVVG EYANACLQVA QDCGTDVLDL 180
  181 WTLMQDSQDF SSYLSDGLHL SPKGNEFLFS HLWPLIEKKV SSLPLLLPYW RDVAEAKPEL 240
  241 SLLGDGDH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 28.69897
Match: 1yzfA
Description: Crystal structure of the lipase/acylhydrolase from Enterococcus faecalis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 1.15974340242656 bayes_pls_golite062009
hydrolase activity 0.755660272658182 bayes_pls_golite062009
binding 0.723787843954977 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.39017969987234 bayes_pls_golite062009
protein binding 0.289427729451854 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle