YRC Public Data Repository - Protein Structure Prediction

Protein:	AHSA1
Organism:	Homo sapiens
Length:	338 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AHSA1.

Description	E-value	Query Range	Subject Range
gi\|73963740 - gi\|73963740\|ref\|XP_537523.2\| PREDICTED: similar to Activator of 90 kDa heat shock protein ATPase hom...	0.0	[1..338]	[1..338]
gi\|114654169, gi... - gi\|114654173\|ref\|XP_001165345.1\| PREDICTED: hypothetical protein isoform 4 [Pan troglodytes], gi\|114...	0.0	[1..338]	[1..338]
gi\|109084442 - gi\|109084442\|ref\|XP_001103794.1\| PREDICTED: AHA1, activator of heat shock 90kDa protein ATPase homol...	0.0	[1..338]	[1..338]
gi\|55730658 - gi\|55730658\|emb\|CAH92050.1\| hypothetical protein [Pongo abelii] gi\|197100599 - gi\|197100599\|ref\|NP_001127499.1\| activator of heat shock 90kDa protein ATPase homolog 1 [Pongo abeli...	0.0	[1..338]	[1..338]
AHSA1_MOUSE - Activator of 90 kDa heat shock protein ATPase homolog 1 OS=Mus musculus GN=Ahsa1 PE=1 SV=2	0.0	[1..338]	[1..338]
gi\|77736277, gi\|... - gi\|77736277\|ref\|NP_001029838.1\| activator of heat shock 90kDa protein ATPase homolog 1 [Bos taurus],...	0.0	[1..338]	[1..338]
gi\|109479740, gi... - gi\|169234816\|ref\|NP_001108506.1\| hypothetical protein LOC681996 [Rattus norvegicus], gi\|165970860\|gb...	0.0	[1..338]	[1..338]

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Predicted Domain #1

Region A:
Residues: [1-194]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKWGEGDPR WIVEERADAT NVNNWHWTER DASNWSTDKL KTLFLAVQVQ NEEGKCEVTE  60
   61 VSKLDGEASI NNRKGKLIFF YEWSVKLNWT GTSKSGVQYK GHVEIPNLSD ENSVDEVEIS 120
  121 VSLAKDEPDT NLVALMKEEG VKLLREAMGI YISTLKTEFT QGMILPTMNG ESVDPVGQPA 180
  181 LKTEERKAKP APSK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	48.39794
Match:	1usvB
Description:	The Structure of the complex between Aha1 and HSP90
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
chaperone binding	2.83340109651263	bayes_pls_golite062009
ATPase regulator activity	2.31076586548557	bayes_pls_golite062009
ATPase activator activity	1.99816875782377	bayes_pls_golite062009
binding	1.41211290001748	bayes_pls_golite062009
protein binding	1.12549021331477	bayes_pls_golite062009
heat shock protein binding	0.87871487226722	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [195-338]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TQARPVGVKI PTCKITLKET FLTSPEELYR VFTTQELVQA FTHAPATLEA DRGGKFHMVD  60
   61 GNVSGEFTDL VPEKHIVMKW RFKSWPEGHF ATITLTFIDK NGETELCMEG RGIPAPEEER 120
  121 TRQGWQRYYF EGIKQTFGYG ARLF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	35.69897
Match:	1x53A
Description:	The solution structure of the C-terminal domain of human Activator of 90 kDa heat shock protein ATPase homolog 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	0.800494322693462	bayes_pls_golite062009
protein binding	0.186935278553638	bayes_pls_golite062009
catalytic activity	0.0116392906163881	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: