YRC Public Data Repository - Protein Structure Prediction

Protein:	GTF2H4
Organism:	Homo sapiens
Length:	462 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GTF2H4.

Description	E-value	Query Range	Subject Range
gi\|62896773 - gi\|62896773\|dbj\|BAD96327.1\| general transcription factor IIH, polypeptide 4, 52kDa variant [Homo sap...	0.0	[1..462]	[1..462]
gi\|47059175, gi\|... - gi\|47059175\|ref\|NP_997666.1\| general transcription factor II H, polypeptide 4 [Rattus norvegicus], g...	0.0	[1..462]	[1..463]
TF2H4_MOUSE - General transcription factor IIH subunit 4 OS=Mus musculus GN=Gtf2h4 PE=1 SV=1	0.0	[1..462]	[1..463]
gi\|73972150 - gi\|73972150\|ref\|XP_848919.1\| PREDICTED: similar to general transcription factor II H, polypeptide 4 ...	0.0	[1..462]	[1..463]
gi\|178056954, gi... - gi\|47496805\|dbj\|BAD08426.2\| general transcription factor IIH, polypeptide 4 [Sus scrofa], gi\|4152916...	0.0	[1..462]	[1..463]
gi\|155371845, gi... - gi\|61870690\|ref\|XP_613734.1\| PREDICTED: similar to general transcription factor II H, polypeptide 4 ...	0.0	[1..462]	[1..463]
gi\|94733612 - gi\|94733612\|emb\|CAK04588.1\| novel protein (zgc:77721) [Danio rerio]	0.0	[11..462]	[4..466]

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Predicted Domain #1

Region A:
Residues: [1-130]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESTPSRGLN RVHLQCRNLQ EFLGGLSPGV LDRLYGHPAT CLAVFRELPS LAKNWVMRML  60
   61 FLEQPLPQAA VALWVKKEFS KAQEESTGLL SGLRIWHTQL LPGGLQGLIL NPIFRQNLRI 120
  121 ALLGGGKAWS

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.354	0.860	RNA polymerase II transcription factor activity	a.4.5	"Winged helix" DNA-binding domain

Predicted Domain #2

Region A:
Residues: [131-297]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDTSQLGPDK HARDVPSLDK YAEERWEVVL HFMVGSPSAA VSQDLAQLLS QAGLMKSTEP  60
   61 GEPPCITSAG FQFLLLDTPA QLWYFMLQYL QTAQSRGMDL VEILSFLFQL SFSTLGKDYS 120
  121 VEGMSDSLLN FLQHLREFGL VFQRKRKSRR YYPTRLAINL SSGVSGA

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [298-462]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGTVHQPGFI VVETNYRLYA YTESELQIAL IALFSEMLYR FPNMVVAQVT RESVQQAIAS  60
   61 GITAQQIIHF LRTRAHPVML KQTPVLPPTI TDQIRLWELE RDRLRFTEGV LYNQFLSQVD 120
  121 FELLLAHARE LGVLVFENSA KRLMVVTPAG HSDVKRFWKR QKHSS

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits