YRC Public Data Repository - Protein Structure Prediction

Protein:	WEE1
Organism:	Homo sapiens
Length:	646 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for WEE1.

Description	E-value	Query Range	Subject Range
gi\|47123300 - gi\|47123300\|gb\|AAH70052.1\| WEE1 homolog (S. pombe) [Homo sapiens]	9.0E-88	[1..646]	[1..646]
gi\|114636085 - gi\|114636085\|ref\|XP_521839.2\| PREDICTED: wee1 tyrosine kinase [Pan troglodytes]	2.0E-87	[1..646]	[1..646]
gi\|76635665, gi\|... - gi\|76635665\|ref\|XP_593176.2\| PREDICTED: similar to WEE1Hu CDK tyrosine 15-kinase isoform 1 [Bos taur...	1.0E-84	[1..646]	[1..646]
gi\|73988828 - gi\|73988828\|ref\|XP_534051.2\| PREDICTED: similar to Wee1-like protein kinase (WEE1hu) [Canis familiar...	4.0E-82	[1..646]	[241..887]
WEE1_MOUSE - Wee1-like protein kinase OS=Mus musculus GN=Wee1 PE=1 SV=2	3.0E-79	[1..646]	[1..646]
gi\|1020095 - gi\|1020095\|dbj\|BAA06624.1\| wee1 tyrosine kinase [Rattus sp.] WEE1_RAT - Wee1-like protein kinase OS=Rattus norvegicus GN=Wee1 PE=1 SV=1	5.0E-79	[1..646]	[1..646]
gi\|62857006 - gi\|62857006\|dbj\|BAD95888.1\| Ser/Thr protein kinase [Lotus japonicus]	8.0E-78	[298..642]	[19..340]

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Predicted Domain #1

Region A:
Residues: [1-278]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFLSRQQPP PPRRAGAACT LRQKLIFSPC SDCEEEEEEE EEEGSGHSTG EDSAFQEPDS  60
   61 PLPPARSPTE PGPERRRSPG PAPGSPGELE EDLLLPGACP GADEAGGGAE GDSWEEEGFG 120
  121 SSSPVKSPAA PYFLGSSFSP VRCGGPGDAS PRGCGARRAG EGRRSPRPDH PGTPPHKTFR 180
  181 KLRLFDTPHT PKSLLSKARG IDSSSVKLRG SSLFMDTEKS GKREFDVRQT PQVNINPFTP 240
  241 DSLLLHSSGQ CRRRKRTYWN DSCGEDMEAS DYELEDET

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [279-578]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPAKRITITE SNMKSRYTTE FHELEKIGSG EFGSVFKCVK RLDGCIYAIK RSKKPLAGSV  60
   61 DEQNALREVY AHAVLGQHSH VVRYFSAWAE DDHMLIQNEY CNGGSLADAI SENYRIMSYF 120
  121 KEAELKDLLL QVGRGLRYIH SMSLVHMDIK PSNIFISRTS IPNAASEEGD EDDWASNKVM 180
  181 FKIGDLGHVT RISSPQVEEG DSRFLANEVL QENYTHLPKA DIFALALTVV CAAGAEPLPR 240
  241 NGDQWHEIRQ GRLPRIPQVL SQEFTELLKV MIHPDPERRP SAMALVKHSV LLSASRKSAE 300
  301

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	50.30103
Match:	1x8bA
Description:	Structure of human Wee1A kinase: kinase domain complexed with inhibitor PD0407824
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [579-646]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLRIELNAEK FKNSLLQKEL KKAQMAKAAA EERALFTDRM ATRSTTQSNR TSRLIGKKMN  60
   61 RSVSLTIY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	59.0
Match:	1omwA
Description:	G-protein coupled receptor kinase 2, N-terminal domain; G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1); G-protein coupled receptor kinase 2
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits