YRC Public Data Repository - Protein Structure Prediction

Protein:	EPS15L1
Organism:	Homo sapiens
Length:	864 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EPS15L1.

Description	E-value	Query Range	Subject Range
gi\|109123809 - gi\|109123809\|ref\|XP_001113811.1\| PREDICTED: similar to epidermal growth factor receptor pathway subs...	4.0E-65	[16..862]	[121..967]
gi\|76621154 - gi\|76621154\|ref\|XP_876634.1\| PREDICTED: similar to epidermal growth factor receptor pathway substrat...	1.0E-63	[1..864]	[1..864]
gi\|50761168 - gi\|50761168\|ref\|XP_418263.1\| PREDICTED: similar to epidermal growth factor receptor pathway substrat...	1.0E-60	[22..864]	[30..860]
gi\|68388302 - gi\|68388302\|ref\|XP_696268.1\| PREDICTED: similar to slow myosin heavy chain 1 [Danio rerio]	1.0E-60	[1..754]	[1986..2742]
gi\|73986258 - gi\|73986258\|ref\|XP_541965.2\| PREDICTED: similar to epidermal growth factor receptor pathway substrat...	2.0E-56	[1..862]	[1..860]
EP15R_MOUSE - Epidermal growth factor receptor substrate 15-like 1 OS=Mus musculus GN=Eps15l1 PE=1 SV=3	4.0E-54	[1..862]	[1..860]

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Predicted Domain #1

Region A:
Residues: [1-574]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAPLIPLSQ QIPTGNSLYE SYYKQVDPAY TGRVGASEAA LFLKKSGLSD IILGKIWDLA  60
   61 DPEGKGFLDK QGFYVALRLV ACAQSGHEVT LSNLNLSMPP PKFHDTSSPL MVTPPSAEAH 120
  121 WAVRVEEKAK FDGIFESLLP INGLLSGDKV KPVLMNSKLP LDVLGRVWDL SDIDKDGHLD 180
  181 RDEFAVAMHL VYRALEKEPV PSALPPSLIP PSKRKKTVFP GAVPVLPASP PPKDSLRSTP 240
  241 SHGSVSSLNS TGSLSPKHSL KQTQPTVNWV VPVADKMRFD EIFLKTDLDL DGYVSGQEVK 300
  301 EIFMHSGLTQ NLLAHIWALA DTRQTGKLSK DQFALAMYFI QQKVSKGIDP PQVLSPDMVP 360
  361 PSERGTPGPD SSGSLGSGEF TGVKELDDIS QEIAQLQREK YSLEQDIREK EEAIRQKTSE 420
  421 VQELQNDLDR ETSSLQELEA QKQDAQDRLD EMDQQKAKLR DMLSDVRQKC QDETQMISSL 480
  481 KTQIQSQESD LKSQEDDLNR AKSELNRLQQ EETQLEQSIQ AGRVQLETII KSLKSTQDEI 540
  541 NQARSKLSQL HESRQEAHRS LEQYDQVLDG AHGA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	31.522879
Match:	1i84S
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [575-864]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLTDLANLSE GVSLAERGSF GAMDDPFKNK ALLFSNNTQE LHPDPFQTED PFKSDPFKGA  60
   61 DPFKGDPFQN DPFAEQQTTS TDPFGGDPFK ESDPFRGSAT DDFFKKQTKN DPFTSDPFTK 120
  121 NPSLPSKLDP FESSDPFSSS SVSSKGSDPF GTLDPFGSGS FNSAEGFADF SQMSKPPPSG 180
  181 PFTSSLGGAG FSDDPFKSKQ DTPALPPKKP APPRPKPPSG KSTPVSQLGS ADFPEAPDPF 240
  241 QPLGADSGDP FQSKKGFGDP FSGKDPFVPS SAAKPSKASA SGFADFTSVS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	7.0
Match:	1deqA
Description:	Fibrinogen
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits