YRC Public Data Repository - Protein Structure Prediction

Protein:	KLK3
Organism:	Homo sapiens
Length:	261 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KLK3.

Description	E-value	Query Range	Subject Range
KLK1_MOUSE - Kallikrein-1 OS=Mus musculus GN=Klk1 PE=1 SV=3	2.0E-79	[1..260]	[1..260]
gi\|55741639, gi\|... - pir\|\|S45303 tissue kallikrein (EC 3.4.21.35) precursor - dog, gi\|55741639\|ref\|NP_001003262.1\| kallik... gi\|55741639 - ref\|NP_001003262.1\| kallikrein 1, renal/pancreas/salivary [Canis familiaris]	2.0E-78	[1..261]	[1..261]
gi\|33637117, gi\|... - gi\|56606017\|ref\|NP_001008416.1\| kallikrein 1 [Bos taurus], gi\|33637117\|gb\|AAQ23715.1\| glandular kall...	7.0E-78	[1..261]	[1..261]
KLK1_RAT - Kallikrein-1 OS=Rattus norvegicus GN=Ngfg PE=2 SV=2	1.0E-77	[1..261]	[1..261]
gi\|30584977, gi\|... - gi\|60653413\|gb\|AAX29401.1\| kallikrein 2 prostatic [synthetic construct], gi\|30584977\|gb\|AAP36761.1\| ...	2.0E-77	[1..261]	[1..261]
KLK2 - kallikrein-related peptidase 2 gi\|123979538, gi... - gi\|60656449\|gb\|AAX32788.1\| kallikrein 2 [synthetic construct], gi\|123994355\|gb\|ABM84779.1\| kallikrei...	2.0E-77	[1..261]	[1..261]

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Predicted Domain #1

Region A:
Residues: [1-261]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWVPVVFLTL SVTWIGAAPL ILSRIVGGWE CEKHSQPWQV LVASRGRAVC GGVLVHPQWV  60
   61 LTAAHCIRNK SVILLGRHSL FHPEDTGQVF QVSHSFPHPL YDMSLLKNRF LRPGDDSSHD 120
  121 LMLLRLSEPA ELTDAVKVMD LPTQEPALGT TCYASGWGSI EPEEFLTPKK LQCVDLHVIS 180
  181 NDVCAQVHPQ KVTKFMLCAG RWTGGKSTCS GDSGGPLVCN GVLQGITSWG SEPCALPERP 240
  241 SLYTKVVHYR KWIKDTIVAN P

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	70.221849
Match:	1spjA
Description:	STRUCTURE OF MATURE HUMAN TISSUE KALLIKREIN (HUMAN KALLIKREIN 1 OR KLK1) AT 1.70 ANGSTROM RESOLUTION WITH VACANT ACTIVE SITE
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits