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View Structure Prediction Details

Protein: CPT1B
Organism: Homo sapiens
Length: 772 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CPT1B.

Description E-value Query
Range
Subject
Range
gi|114687087 - gi|114687087|ref|XP_525636.2| PREDICTED: carnitine palmitoyltransferase 1B [Pan troglodytes]
0.0 [1..772] [72..843]
gi|1762533 - gi|1762533|gb|AAC51122.1| carnitine palmitoyltransferase I [Homo sapiens]
0.0 [1..772] [1..772]
gi|67969054 - gi|67969054|dbj|BAE00882.1| unnamed protein product [Macaca fascicularis]
0.0 [1..772] [1..772]
CPT1B_MOUSE - Carnitine O-palmitoyltransferase 1, muscle isoform OS=Mus musculus GN=Cpt1b PE=1 SV=1
0.0 [1..772] [1..772]
gi|73968823 - gi|73968823|ref|XP_538305.2| PREDICTED: similar to carnitine palmitoyltransferase 1B isoform a isofo...
0.0 [1..772] [1..772]
CPT1B_RAT - Carnitine O-palmitoyltransferase 1, muscle isoform OS=Rattus norvegicus GN=Cpt1b PE=1 SV=1
0.0 [1..772] [1..772]

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Predicted Domain #1
Region A:
Residues: [1-79]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEAHQAVAF QFTVTPDGVD FRLSREALKH VYLSGINSWK KRLIRIKNGI LRGVYPGSPT  60
   61 SWLVVIMATV GSSFCNVDI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [80-165]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLGLVSCIQR CLPQGCGPYQ TPQTRALLSM AIFSTGVWVT GIFFFRQTLK LLLCYHGWMF  60
   61 EMHGKTSNLT RIWAMCIRLL SSRHPM

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [166-772]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LYSFQTSLPK LPVPRVSATI QRYLESVRPL LDDEEYYRME LLAKEFQDKT APRLQKYLVL  60
   61 KSWWASNYVS DWWEEYIYLR GRSPLMVNSN YYVMDLVLIK NTDVQAARLG NIIHAMIMYR 120
  121 RKLDREEIKP VMALGIVPMC SYQMERMFNT TRIPGKDTDV LQHLSDSRHV AVYHKGRFFK 180
  181 LWLYEGARLL KPQDLEMQFQ RILDDPSPPQ PGEEKLAALT AGGRVEWAQA RQAFFSSGKN 240
  241 KAALEAIERA AFFVALDEES YSYDPEDEAS LSLYGKALLH GNCYNRWFDK SFTLISFKNG 300
  301 QLGLNAEHAW ADAPIIGHLW EFVLGTDSFH LGYTETGHCL GKPNPALAPP TRLQWDIPKQ 360
  361 CQAVIESSYQ VAKALADDVE LYCFQFLPFG KGLIKKCRTS PDAFVQIALQ LAHFRDRGKF 420
  421 CLTYEASMTR MFREGRTETV RSCTSESTAF VQAMMEGSHT KADLRDLFQK AAKKHQNMYR 480
  481 LAMTGAGIDR HLFCLYLVSK YLGVSSPFLA EVLSEPWRLS TSQIPQSQIR MFDPEQHPNH 540
  541 LGAGGGFGPV ADDGYGVSYM IAGENTIFFH ISSKFSSSET NAQRFGNHIR KALLDIADLF 600
  601 QVPKAYS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1t7nA
Description: Crystal structure of the M564G mutant of murine CrAT
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
carnitine O-acyltransferase activity 7.54616819269984 bayes_pls_golite062009
carnitine O-acetyltransferase activity 7.38318207912192 bayes_pls_golite062009
choline O-acetyltransferase activity 6.09272417016149 bayes_pls_golite062009
octanoyltransferase activity 4.52268776339565 bayes_pls_golite062009
O-octanoyltransferase activity 4.52268776339565 bayes_pls_golite062009
carnitine O-octanoyltransferase activity 4.52268776339565 bayes_pls_golite062009
S-acyltransferase activity 4.44987112475286 bayes_pls_golite062009
carnitine O-palmitoyltransferase activity 3.83467723502092 bayes_pls_golite062009
O-palmitoyltransferase activity 3.83467723502092 bayes_pls_golite062009
transferase activity, transferring acyl groups 3.7327637835604 bayes_pls_golite062009
O-acyltransferase activity 3.7101056995294 bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity 3.56004160262054 bayes_pls_golite062009
dihydrolipoyllysine-residue acetyltransferase activity 3.36143851730669 bayes_pls_golite062009
S-acetyltransferase activity 3.32990830846882 bayes_pls_golite062009
acyltransferase activity 3.08588280042054 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 3.027770031317 bayes_pls_golite062009
S-succinyltransferase activity 3.02354522717247 bayes_pls_golite062009
dihydrolipoyllysine-residue succinyltransferase activity 3.02354522717247 bayes_pls_golite062009
O-acetyltransferase activity 2.37098434941789 bayes_pls_golite062009
palmitoyltransferase activity 2.23754077046213 bayes_pls_golite062009
succinyltransferase activity 2.08404693277798 bayes_pls_golite062009
choline binding 1.59193088660278 bayes_pls_golite062009
catalytic activity 1.51562638409295 bayes_pls_golite062009
acetyltransferase activity 1.12787027896966 bayes_pls_golite062009
transferase activity 1.08341671157927 bayes_pls_golite062009
binding 0.999555841397607 bayes_pls_golite062009
pyruvate dehydrogenase activity 0.85838145786229 bayes_pls_golite062009
protein binding 0.104367069798378 bayes_pls_golite062009
amine binding 0.0679262278252373 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle