YRC Public Data Repository - Protein Structure Prediction

Protein:	MIA
Organism:	Homo sapiens
Length:	131 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MIA.

Description	E-value	Query Range	Subject Range
gi\|60653679, gi\|... - gi\|60653679\|gb\|AAX29533.1\| melanoma inhibitory activity [synthetic construct], gi\|30584389\|gb\|AAP364...	8.0E-30	[1..131]	[1..131]
gi\|73948308 - gi\|73948308\|ref\|XP_541610.2\| PREDICTED: similar to Melanoma derived growth regulatory protein precur...	1.0E-27	[1..131]	[1..131]
MIA_MOUSE - Melanoma-derived growth regulatory protein OS=Mus musculus GN=Mia PE=2 SV=2	2.0E-27	[1..131]	[1..130]
MIA_BOVIN - Melanoma-derived growth regulatory protein OS=Bos taurus GN=MIA PE=2 SV=1	3.0E-27	[1..131]	[1..130]
MIA_RAT - Melanoma-derived growth regulatory protein OS=Rattus norvegicus GN=Mia PE=2 SV=2	4.0E-27	[1..131]	[1..130]
gi\|109124844, gi... - gi\|109124844\|ref\|XP_001098701.1\| PREDICTED: melanoma inhibitory activity isoform 2 [Macaca mulatta],...	2.0E-26	[1..131]	[1..131]
gi\|14277752, gi\|... - gi\|22218890\|pdb\|1K0X\|A Chain A, Solution Structure Of Melanoma Inhibitory Activity Protein, gi\|14277...	1.0E-22	[25..131]	[2..108]

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Predicted Domain #1

Region A:
Residues: [1-131]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARSLVCLGV IILLSAFSGP GVRGGPMPKL ADRKLCADQE CSHPISMAVA LQDYMAPDCR  60
   61 FLTIHRGQVV YVFSKLKGRG RLFWGGSVQG DYYGDLAARL GYFPSSIVRE DQTLKPGKVD 120
  121 VKTDKWDFYC Q

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	24.09691
Match:	1i1jA
Description:	Melanoma inhibitory activity protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.0198140785578	bayes_pls_golite062009
protein binding	1.85368024495439	bayes_pls_golite062009
receptor binding	1.46964167495514	bayes_pls_golite062009
cytoskeletal protein binding	0.313587086905048	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: