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View Structure Prediction Details

Protein: CENPB
Organism: Homo sapiens
Length: 599 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CENPB.

Description E-value Query
Range
Subject
Range
CENPB_MOUSE, CEN... - Major centromere autoantigen B OS=Mus musculus GN=Cenpb PE=2 SV=1, (P27790) Major centromere autoant...
296.0 [0..1] [389..1]
gi|1408257 - gi|1408257|gb|AAC49418.1| putative transposase [Magnaporthe grisea]
293.0 [0..10] [416..7]
gi|38103321, gi|... - gi|39943554|ref|XP_361314.1| hypothetical protein MG03788.4 [Magnaporthe grisea 70-15], gb|EAA50029....
291.0 [0..10] [416..84]
gi|109470842, gi... - gi|34858726|ref|XP_342522.1| PREDICTED: similar to Major centromere autoantigen B (Centromere protei...
285.0 [0..1] [389..1]

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Predicted Domain #1
Region A:
Residues: [1-177]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGPKRRQLTF REKSRIIQEV EENPDLRKGE IARRFNIPPS TLSTILKNKR AILASERKYG  60
   61 VASTCRKTNK LSPYDKLEGL LIAWFQQIRA AGLPVKGIIL KEKALRIAEE LGMDDFTASN 120
  121 GWLDRFRRRH GVVSCSGVAR ARARNAAPRT PAAPASPAAV PSEGSGGSTT GWRAREE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.0
Match: 1hlvA
Description: DNA-binding domain of centromere binding protein B (CENP-B)
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [178-390]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPPSVAEGYA SQDVFSATET SLWYDFLPDQ AAGLCGGDGR PRQATQRLSV LLCANADGSE  60
   61 KLPPLVAGKS AKPRAGQAGL PCDYTANSKG GVTTQALAKY LKALDTRMAA ESRRVLLLAG 120
  121 RLAAQSLDTS GLRHVQLAFF PPGTVHPLER GVVQQVKGHY RQAMLLKAMA ALEGQDPSGL 180
  181 QLGLTEALHF VAAAWQAVEP SDIAACFREA GFG

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 69.744727
Match: PF03184.6
Description: No description for PF03184.6 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [391-525]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGPNATITTS LKSEGEEEEE EEEEEEEEEG EGEEEEEEGE EEEEEGGEGE ELGEEEEVEE  60
   61 EGDVDSDEEE EEDEESSSEG LEAEDWAQGV VEAGGSFGAY GAQEEAQCPT LHFLEGGEDS 120
  121 DSDSEEEDDE EEDDE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [526-599]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEDDDDDEED GDEVPVPSFG EAMAYFAMVK RYLTSFPIDD RVQSHILHLE HDLVHVTRKN  60
   61 HARQAGVRGL GHQS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.045757
Match: 1ufiA
Description: Crystal structure of the dimerization domain of human CENP-B
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle