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View Structure Prediction Details

Protein: KCNQ2
Organism: Homo sapiens
Length: 872 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KCNQ2.

Description E-value Query
Range
Subject
Range
gi|2801452 - gi|2801452|gb|AAB97315.1| potassium channel; KvEBN1 [Homo sapiens]
0.0 [1..872] [1..872]
gi|54873639, gi|... - gi|54873639|ref|NP_034741.2| potassium voltage-gated channel KQT-like protein 2 isoform 1 [Mus muscu...
gi|162319120 - gi|162319120|gb|AAI56316.1| Potassium voltage-gated channel, subfamily Q, member 2 [synthetic constr...
0.0 [1..872] [1..870]

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Predicted Domain #1
Region A:
Residues: [1-366]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVQKSRNGGV YPGPSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR GSILSKPRAG  60
   61 GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF LLVFSCLVLS VFSTIKEYEK 120
  121 SSEGALYILE IVTIVVFGVE YFVRIWAAGC CCRYRGWRGR LKFARKPFCV IDIMVLIASI 180
  181 AVLAAGSQGN VFATSALRSL RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELVTAWYIGF 240
  241 LCLILASFLV YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI 300
  301 GVSFFALPAG ILGSGFALKV QEQHRQKHFE KRRNPAAGLI QSAWRFYATN LSRTDLHSTW 360
  361 QYYERT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.522879
Match: 2a79B
Description: Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [367-517]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTVPMYSSQT QTYGASRLIP PLNQLELLRN LKSKSGLAFR KDPPPEPSPS KGSPCRGPLC  60
   61 GCCPGRSSQK VSLKDRVFSS PRGVAAKGKG SPQAQTVRRS PSADQSLEDS PSKVPKSWSF 120
  121 GDRSRARQAF RIKGAASRQN SEEASLPGED I

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.522879
Match: 1lnqA
Description: Potassium channel-related protein MthK
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [518-707]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VDDKSCPCEF VTEDLTPGLK VSIRAVCVMR FLVSKRKFKE SLRPYDVMDV IEQYSAGHLD  60
   61 MLSRIKSLQS RVDQIVGRGP AITDKDRTKG PAEAELPEDP SMMGRLGKVE KQVLSMEKKL 120
  121 DFLVNIYMQR MGIPPTETEA YFGAKEPEPA PPYHSPEDSR EHVDRHGCIV KIVRSSSSTG 180
  181 QKNFSAPPAA 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [708-872]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPVQCPPSTS WQPQSHPRQG HGTSPVGDHG SLVRIPPPPA HERSLSAYGG GNRASMEFLR  60
   61 QEDTPGCRPP EGNLRDSDTS ISIPSVDHEE LERSFSGFSI SQSKENLDAL NSCYAAVAPC 120
  121 AKVRPYIAEG ESDTDSDLCT PCGPPPRSAT GEGPFGDVGW AGPRK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle