YRC Public Data Repository - Protein Structure Prediction

Protein:	CDH1
Organism:	Homo sapiens
Length:	882 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CDH1.

Description	E-value	Query Range	Subject Range
gi\|31075 - gi\|31075\|emb\|CAA79356.1\| E-cadherin [Homo sapiens]	0.0	[1..882]	[1..882]
CADH1_BOVIN - Cadherin-1 OS=Bos taurus GN=CDH1 PE=2 SV=1	0.0	[1..882]	[1..882]
CADH1_RAT - Cadherin-1 OS=Rattus norvegicus GN=Cdh1 PE=1 SV=1	0.0	[1..882]	[1..886]
gi\|114663332 - gi\|114663332\|ref\|XP_001168150.1\| PREDICTED: cadherin 1, type 1 isoform 2 [Pan troglodytes]	0.0	[1..882]	[1..882]
CADH1_PONAB - Cadherin-1 OS=Pongo abelii GN=CDH1 PE=2 SV=1 CADH1_PONPY - Epithelial-cadherin precursor - Pongo pygmaeus (Orangutan)	0.0	[1..882]	[1..882]
gi\|1587676 - gi\|1587676\|prf\|\|2207206A E-cadherin	0.0	[1..882]	[1..886]
gi\|73957458 - gi\|73957458\|ref\|XP_536807.2\| PREDICTED: similar to Epithelial-cadherin precursor (E-cadherin) (Uvomo...	0.0	[1..882]	[77..965]
CADH1_MOUSE - Cadherin-1 OS=Mus musculus GN=Cdh1 PE=1 SV=1	0.0	[1..882]	[1..884]

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Predicted Domain #1

Region A:
Residues: [1-882]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGPWSRSLSA LLLLLQVSSW LCQEPEPCHP GFDAESYTFT VPRRHLERGR VLGRVNFEDC  60
   61 TGRQRTAYFS LDTRFKVGTD GVITVKRPLR FHNPQIHFLV YAWDSTYRKF STKVTLNTVG 120
  121 HHHRPPPHQA SVSGIQAELL TFPNSSPGLR RQKRDWVIPP ISCPENEKGP FPKNLVQIKS 180
  181 NKDKEGKVFY SITGQGADTP PVGVFIIERE TGWLKVTEPL DRERIATYTL FSHAVSSNGN 240
  241 AVEDPMEILI TVTDQNDNKP EFTQEVFKGS VMEGALPGTS VMEVTATDAD DDVNTYNAAI 300
  301 AYTILSQDPE LPDKNMFTIN RNTGVISVVT TGLDRESFPT YTLVVQAADL QGEGLSTTAT 360
  361 AVITVTDTND NPPIFNPTTY KGQVPENEAN VVITTLKVTD ADAPNTPAWE AVYTILNDDG 420
  421 GQFVVTTNPV NNDGILKTAK GLDFEAKQQY ILHVAVTNVV PFEVSLTTST ATVTVDVLDV 480
  481 NEAPIFVPPE KRVEVSEDFG VGQEITSYTA QEPDTFMEQK ITYRIWRDTA NWLEINPDTG 540
  541 AISTRAELDR EDFEHVKNST YTALIIATDN GSPVATGTGT LLLILSDVND NAPIPEPRTI 600
  601 FFCERNPKPQ VINIIDADLP PNTSPFTAEL THGASANWTI QYNDPTQESI ILKPKMALEV 660
  661 GDYKINLKLM DNQNKDQVTT LEVSVCDCEG AAGVCRKAQP VEAGLQIPAI LGILGGILAL 720
  721 LILILLLLLF LRRRAVVKEP LLPPEDDTRD NVYYYDEEGG GEEDQDFDLS QLHRGLDARP 780
  781 EVTRNDVAPT LMSVPRYLPR PANPDEIGNF IDENLKAADT DPTAPPYDSL LVFDYEGSGS 840
  841 EAASLSSLNS SESDKDQDYD YLNEWGNRFK KLADMYGGGE DD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	174.0
Match:	1q55A
Description:	W-shaped trans interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits