YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|7243127
Organism:	Homo sapiens
Length:	463 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|7243127.

Description	E-value	Query Range	Subject Range
gi\|168278869 - gi\|168278869\|dbj\|BAG11314.1\| AMSH-like protease [synthetic construct] gi\|55957584, gi\|... - gi\|55957584\|emb\|CAI13862.1\| novel Mov34/MPN/PAD-1 family domain containing protein (FLJ31524) [Homo ...	0.0	[3..463]	[1..461]
gi\|114631675 - gi\|114631675\|ref\|XP_001140148.1\| PREDICTED: associated molecule with the SH3 domain of STAM (AMSH) l...	0.0	[3..463]	[1..461]
gi\|109089856 - gi\|109089856\|ref\|XP_001083976.1\| PREDICTED: similar to associated molecule with the SH3 domain of ST...	0.0	[3..463]	[1..461]
STALP_PONAB - AMSH-like protease OS=Pongo abelii GN=STAMBPL1 PE=2 SV=1 STALP_PONPY - AMSH-like protease - Pongo pygmaeus (Orangutan)	0.0	[3..428]	[1..426]
STALP_MOUSE - AMSH-like protease OS=Mus musculus GN=Stambpl1 PE=1 SV=1 gi\|55742879 - ref\|NP_083958.3\| AMSH-family protein [Mus musculus]	0.0	[3..428]	[1..426]
gi\|165970954, gi... - gi\|169234828\|ref\|NP_001108520.1\| hypothetical protein LOC687696 [Rattus norvegicus], gi\|165970954\|gb...	0.0	[3..428]	[1..426]
gi\|115497652, gi... - gi\|76654504\|ref\|XP_582671.2\| PREDICTED: similar to associated molecule with the SH3 domain of STAM (...	0.0	[3..428]	[1..426]

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Predicted Domain #1

Region A:
Residues: [1-209]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNMDQPFTVN SLKKLAAMPD HTDVSLSPEE RVRALSKLGC NITISEDITP RRYFRSGVEM  60
   61 ERMASVYLEE GNLENAFVLY NKFITLFVEK LPNHRDYQQC AVPEKQDIMK KLKEIAFPRT 120
  121 DELKNDLLKK YNVEYQEYLQ SKNKYKAEIL KKLEHQRLIE AERKRIAQMR QQQLESEQFL 180
  181 FFEDQLKKQE LARGQMRSQQ TSGLSEQID

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	23.39794
Match:	2a9uA
Description:	Structure of the N-terminal domain of Human Ubiquitin carboxyl-terminal hydrolase 8 (USP8)
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [210-463]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSALSCFSTH QNNSLLNVFA DQPNKSDATN YASHSPPVNR ALTPAATLSA VQNLVVEGLR  60
   61 CVVLPEDLCH KFLQLAESNT VRGIETCGIL CGKLTHNEFT ITHVIVPKQS AGPDYCDMEN 120
  121 VEELFNVQDQ HDLLTLGWIH THPTQTAFLS SVDLHTHCSY QLMLPEAIAI VCSPKHKDTG 180
  181 IFRLTNAGML EVSACKKKGF HPHTKEPRLF SIQKFLSGII SGTALEMEPL KIGYGPNGFP 240
  241 LLGISRSSSP SEQL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	50.0
Match:	2p87A
Description:	No description for 2p87A was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits