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View Structure Prediction Details

Protein: gi|7243133
Organism: Homo sapiens
Length: 437 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|7243133.

Description E-value Query
Range		 Subject
Range
gi|28972730 - gi|28972730|dbj|BAC65781.1| mKIAA1376 protein [Mus musculus]
 0.0 [4..437] [20..453]
ARRD3_BOVIN - Arrestin domain-containing protein 3 OS=Bos taurus GN=ARRDC3 PE=2 SV=1
 0.0 [24..437] [1..414]
gi|168278871 - gi|168278871|dbj|BAG11315.1| arrestin domain-containing protein 3 [synthetic construct]
ARRDC3 - arrestin domain containing 3
 0.0 [24..437] [1..414]
ARRD3_PONPY - Arrestin domain-containing protein 3 - Pongo pygmaeus (Orangutan)
ARRD3_PONAB - Arrestin domain-containing protein 3 OS=Pongo abelii GN=ARRDC3 PE=2 SV=1
 0.0 [24..437] [1..414]
gi|114599171 - gi|114599171|ref|XP_526859.2| PREDICTED: arrestin domain containing 3 isoform 3 [Pan troglodytes]
 0.0 [24..437] [1..414]
gi|57084867 - gi|57084867|ref|XP_546029.1| PREDICTED: similar to arrestin domain containing 3 isoform 1 [Canis fam...
 0.0 [24..437] [1..414]
gi|109077981 - gi|109077981|ref|XP_001089534.1| PREDICTED: similar to arrestin domain containing 3 isoform 3 [Macac...
 0.0 [24..437] [1..414]
ARRD3_RAT - Arrestin domain-containing protein 3 OS=Rattus norvegicus GN=Arrdc3 PE=2 SV=1
 0.0 [24..437] [1..414]

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Predicted Domain #1
Region A:
Residues: [1-341] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSHFICDLDF FVLHYIFIDF VINMVLGKVK SLTISFDCLN DSNVPVYSSG DTVSGRVNLE  60
   61 VTGEIRVKSL KIHARGHAKV RWTESRNAGS NTAYTQNYTE EVEYFNHKDI LIGHERDDDN 120
  121 SEEGFHTIHS GRHEYAFSFE LPQTPLATSF EGRHGSVRYW VKAELHRPWL LPVKLKKEFT 180
  181 VFEHIDINTP SLLSPQAGTK EKTLCCWFCT SGPISLSAKI ERKGYTPGES IQIFAEIENC 240
  241 SSRMVVPKAA IYQTQAFYAK GKMKEVKQLV ANLRGESLSS GKTETWNGKL LKIPPVSPSI 300
  301 LDCSIIRVEY SLMVYVDIPG AMDLFLNLPL VIGTIPLHPF G

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 68.09691
Match: 1jsyA
Description: Arrestin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.65544526722793 bayes_pls_golite062009
protein binding 2.55331587515144 bayes_pls_golite062009
ligand-gated ion channel activity 1.56260928865312 bayes_pls_golite062009
ligand-gated channel activity 1.56260928865312 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.367041097706985 bayes_pls_golite062009
cytoskeletal protein binding 0.28077587787197 bayes_pls_golite062009
cation transmembrane transporter activity 0.0630651159608981 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [342-437] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRTSSVSSQC SMNMNWLSLS LPERPEAPPS YAEVVTEEQR RNNLAPVSAC DDFERALQGP  60
   61 LFAYIQEFRF LPPPLYSEID PNPDQSADDR PSCPSR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.317 N/A N/A c.47.1 Thioredoxin-like

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