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View Structure Prediction Details

Protein: LMNA
Organism: Homo sapiens
Length: 664 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LMNA.

Description E-value Query
Range		 Subject
Range
gi|114560153 - gi|114560153|ref|XP_513875.2| PREDICTED: lamin A/C [Pan troglodytes]
 3.0E-89 [1..664] [437..1099]
gi|109017515 - gi|109017515|ref|XP_001113604.1| PREDICTED: lamin A/C [Macaca mulatta]
 1.0E-62 [18..664] [81..726]
gi|57014047 - gi|57014047|gb|AAW32540.1| lamin A/C transcript variant 1 [Homo sapiens]
 3.0E-62 [1..664] [1..664]
LMNA_PIG - Prelamin-A/C OS=Sus scrofa GN=LMNA PE=3 SV=1
 3.0E-60 [1..664] [1..664]
LMNA_RAT - Prelamin-A/C OS=Rattus norvegicus GN=Lmna PE=1 SV=1
 4.0E-59 [1..664] [1..665]

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Predicted Domain #1
Region A:
Residues: [1-333] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METPSQRRAT RSGAQASSTP LSPTRITRLQ EKEDLQELND RLAVYIDRVR SLETENAGLR  60
   61 LRITESEEVV SREVSGIKAA YEAELGDARK TLDSVAKERA RLQLELSKVR EEFKELKARN 120
  121 TKKEGDLIAA QARLKDLEAL LNSKEAALST ALSEKRTLEG ELHDLRGQVA KLEAALGEAK 180
  181 KQLQDEMLRR VDAENRLQTM KEELDFQKNI YSEELRETKR RHETRLVEID NGKQREFESR 240
  241 LADALQELRA QHEDQVEQYK KELEKTYSAK LDNARQSAER NSNLVGAAHE ELQQSRIRID 300
  301 SLSAQLSQLQ KQLAAKEAKL RDLEDSLARE RDT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.0
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [334-447] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRRLLAEKER EMAEMRARMQ QQLDEYQELL DIKLALDMEI HAYRKLLEGE EERLRLSPSP  60
   61 TSQRSRGRAS SHSSQTQGGG SVTKKRKLES TESRSSFSQH ARTSGRVAVE EVDE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.30103
Match: 2dfsA
Description: No description for 2dfsA was found.

Predicted Domain #3
Region A:
Residues: [448-573] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGKFVRLRNK SNEDQSMGNW QIKRQNGDDP LLTYRFPPKF TLKAGQVVTI WAAGAGATHS  60
   61 PPTDLVWKAQ NTWGCGNSLR TALINSTGEE VAMRKLVRSV TVVEDDEDED GDDLLHHHHG 120
  121 SHCSSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.045757
Match: 1ivtA
Description: Lamin A/C globular tail domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.1423615717875 bayes_pls_golite062009
protein binding 1.15753975552197 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [574-664] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDPAEYNLRS RTVLCGTCGQ PADKASASGS GAQVGGPISS GSSASSVTVT RSYRSVGGSG  60
   61 GGSFGDNLVT RSYLLGNSSP RTQSPQNCSI M

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle