YRC Public Data Repository - Protein Structure Prediction

Protein:	ERO1L
Organism:	Homo sapiens
Length:	468 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ERO1L.

Description	E-value	Query Range	Subject Range
gi\|114653045 - gi\|114653045\|ref\|XP_509950.2\| PREDICTED: ERO1-like [Pan troglodytes]	0.0	[1..468]	[1..468]
gi\|14250470 - gi\|14250470\|gb\|AAH08674.1\| ERO1-like (S. cerevisiae) [Homo sapiens]	0.0	[1..468]	[1..468]
gi\|109083588 - gi\|109083588\|ref\|XP_001103965.1\| PREDICTED: ERO1-like isoform 3 [Macaca mulatta]	0.0	[1..468]	[1..468]
gi\|73963815 - gi\|73963815\|ref\|XP_547813.2\| PREDICTED: similar to ERO1-like protein alpha precursor (ERO1-Lalpha) (...	0.0	[1..468]	[1..468]
ERO1A_MOUSE - ERO1-like protein alpha OS=Mus musculus GN=Ero1a PE=1 SV=2	0.0	[19..468]	[19..464]
gi\|19924061, gi\|... - gi\|19924061\|ref\|NP_612537.1\| ERO1-like [Rattus norvegicus], gi\|18250366\|gb\|AAL61547.1\| oxidoreductas...	0.0	[19..468]	[19..464]
gi\|76626596 - gi\|76626596\|ref\|XP_589287.2\| PREDICTED: similar to ERO1-like protein alpha precursor (ERO1-Lalpha) (...	0.0	[39..468]	[1..430]

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Predicted Domain #1

Region A:
Residues: [1-468]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGRGWGFLFG LLGAVWLLSS GHGEEQPPET AAQRCFCQVS GYLDDCTCDV ETIDRFNNYR  60
   61 LFPRLQKLLE SDYFRYYKVN LKRPCPFWND ISQCGRRDCA VKPCQSDEVP DGIKSASYKY 120
  121 SEEANNLIEE CEQAERLGAV DESLSEETQK AVLQWTKHDD SSDNFCEADD IQSPEAEYVD 180
  181 LLLNPERYTG YKGPDAWKIW NVIYEENCFK PQTIKRPLNP LASGQGTSEE NTFYSWLEGL 240
  241 CVEKRAFYRL ISGLHASINV HLSARYLLQE TWLEKKWGHN ITEFQQRFDG ILTEGEGPRR 300
  301 LKNLYFLYLI ELRALSKVLP FFERPDFQLF TGNKIQDEEN KMLLLEILHE IKSFPLHFDE 360
  361 NSFFAGDKKE AHKLKEDFRL HFRNISRIMD CVGCFKCRLW GKLQTQGLGT ALKILFSEKL 420
  421 IANMPESGPS YEFHLTRQEI VSLFNAFGRI STSVKELENF RNLLQNIH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	118.0
Match:	1rq1A
Description:	Structure of Ero1p, Source of Disulfide Bonds for Oxidative Protein Folding in the Cell
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on sulfur group of donors	3.04541306149882	bayes_pls_golite062009
thiol oxidase activity	1.56067935587779	bayes_pls_golite062009
binding	1.51315006963036	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor	1.31287436426921	bayes_pls_golite062009
protein disulfide oxidoreductase activity	1.25764823859811	bayes_pls_golite062009
unfolded protein binding	1.21113889423637	bayes_pls_golite062009
catalytic activity	1.09506175640279	bayes_pls_golite062009
protein binding	0.524855475418758	bayes_pls_golite062009
disulfide oxidoreductase activity	0.384901602591813	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: