YRC Public Data Repository - Protein Structure Prediction

Protein:	HOXC5
Organism:	Homo sapiens
Length:	222 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HOXC5.

Description	E-value	Query Range	Subject Range
HXC5_MOUSE - Homeobox protein Hox-C5 OS=Mus musculus GN=Hoxc5 PE=2 SV=3 tr\|M3X6W1\|M3X6W1... - Homeobox C5 OS=Felis catus GN=HOXC5 PE=3 SV=1 gi\|157822081, gi... - ref\|XP_347244.1\| similar to homeo box C5 [Rattus norvegicus], gi\|27665528\|ref\|XP_235702.1\| PREDICTE... gi\|149714970 - gi\|149714970\|ref\|XP_001504605.1\| PREDICTED: similar to Homeobox protein Hox-C5 (Hox-3.4) (Hox-6.2) [...	3.0E-37	[1..222]	[1..222]
gi\|73996360 - gi\|73996360\|ref\|XP_849475.1\| PREDICTED: similar to homeo box C5 [Canis familiaris]	2.0E-36	[1..222]	[1..222]
HXC5_MOUSE - (P32043) Homeobox protein Hox-C5 (Hox-3.4) (Hox-6.2)	5.0E-36	[1..222]	[1..222]
gi\|4322076 - gi\|4322076\|gb\|AAD15947.1\| homeobox protein [Danio rerio]	3.0E-35	[1..218]	[1..210]
gi\|47213840 - gi\|47213840\|emb\|CAG00644.1\| unnamed protein product [Tetraodon nigroviridis]	3.0E-34	[1..209]	[1..209]
gi\|116294310 - gi\|116294310\|gb\|AAP79287.2\| hox 7 [Saccoglossus kowalevskii]	3.0E-34	[1..220]	[1..217]
gi\|154425967, gi... - gi\|76609634\|ref\|XP_590969.2\| PREDICTED: similar to Homeobox D4 [Bos taurus], gi\|155371905\|ref\|NP_001...	1.0E-33	[1..218]	[3..220]
gi\|34484444 - gi\|34484444\|gb\|AAQ72844.1\| HoxB6b [Sphoeroides nephelus]	3.0E-33	[1..215]	[1..215]

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Predicted Domain #1

Region A:
Residues: [1-154]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSYVANSFY KQSPNIPAYN MQTCGNYGSA SEVQASRYCY GGLDLSITFP PPAPSNSLHG  60
   61 VDMAANPRAH PDRPACSAAA APGHAPGRDE AAPLNPGMYS QKAARPALEE RAKSSGEIKE 120
  121 EQAQTGQPAG LSQPPAPPQI YPWMTKLHMS HETD

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [155-222]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKRSRTSYTR YQTLELEKEF HFNRYLTRRR RIEIANNLCL NERQIKIWFQ NRRMKWKKDS  60
   61 KMKSKEAL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	30.221849
Match:	1homA
Description:	DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nucleic acid binding	4.51452285155271	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: