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View Structure Prediction Details

Protein: MVP
Organism: Homo sapiens
Length: 893 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MVP.

Description E-value Query
Range
Subject
Range
MVP_PONAB - Major vault protein OS=Pongo abelii GN=MVP PE=2 SV=3
MVP_PONPY - Major vault protein - Pongo pygmaeus (Orangutan)
0.0 [1..893] [1..893]
gi|1097308, gi|1... - gi|1362855|pir||S57723 lrp protein - human, gi|1097308|prf||2113368A drug resistance-related protein...
0.0 [1..874] [1..874]
gi|7514005, gi|1... - gi|7514005|pir||I53908 major vault protein - rat, gi|1093617|prf||2104283A major vault protein
0.0 [1..880] [11..888]
gi|74204306, gi|... - gi|74207652|dbj|BAE40071.1| unnamed protein product [Mus musculus], gi|74204306|dbj|BAE39910.1| unna...
0.0 [1..851] [10..860]
gi|109287858, gi... - gi|110350007|ref|NP_001036027.1| lung resistance-related protein [Felis catus], gi|109287858|dbj|BAE...
0.0 [1..890] [1..890]
gi|73958475 - gi|73958475|ref|XP_536910.2| PREDICTED: similar to major vault protein [Canis familiaris]
0.0 [1..877] [1..877]

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Predicted Domain #1
Region A:
Residues: [1-99]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATEEFIIRI PPYHYIHVLD QNSNVSRVEV GPKTYIRQDN ERVLFAPMRM VTVPPRHYCT  60
   61 VANPVSRDAQ GLVLFDVTGQ VRLRHADLEI RLAQDPFPL

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 23.958607
Match: PF01505.9
Description: No description for PF01505.9 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [100-232]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YPGEVLEKDI TPLQVVLPNT ALHLKALLDF EDKDGDKVVA GDEWLFEGPG TYIPRKEVEV  60
   61 VEIIQATIIR QNQALRLRAR KECWDRDGKE RVTGEEWLVT TVGAYLPAVF EEVLDLVDAV 120
  121 ILTEKTALHL RAR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 52.0
Match: 1y7xA
Description: Solution structure of a two-repeat fragment of major vault protein
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [233-430]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RNFRDFRGVS RRTGEEWLVT VQDTEAHVPD VHEEVLGVVP ITTLGPHNYC VILDPVGPDG  60
   61 KNQLGQKRVV KGEKSFFLQP GEQLEQGIQD VYVLSEQQGL LLRALQPLEE GEDEEKVSHQ 120
  121 AGDHWLIRGP LEYVPSAKVE VVEERQAIPL DENEGIYVQD VKTGKVRAVI GSTYMLTQDE 180
  181 VLWEKELPPG VEELLNKG

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.86
Match: 1y7xA
Description: Solution structure of a two-repeat fragment of major vault protein
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [431-550]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QDPLADRGEK DTAKSLQPLA PRNKTRVVSY RVPHNAAVQV YDYREKRARV VFGPELVSLG  60
   61 PEEQFTVLSL SAGRPKRPHA RRALCLLLGP DFFTDVITIE TADHARLQLQ LAYNWHFEVN 120
  121 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [551-893]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRKDPQETAK LFSVPDFVGD ACKAIASRVR GAVASVTFDD FHKNSARIIR TAVFGFETSE  60
   61 AKGPDGMALP RPRDQAVFPQ NGLVVSSVDV QSVEPVDQRT RDALQRSVQL AIEITTNSQE 120
  121 AAAKHEAQRL EQEARGRLER QKILDQSEAE KARKELLELE ALSMAVESTG TAKAEAESRA 180
  181 EAARIEGEGS VLQAKLKAQA LAIETEAELQ RVQKVRELEL VYARAQLELE VSKAQQLAEV 240
  241 EVKKFKQMTE AIGPSTIRDL AVAGPEMQVK LLQSLGLKST LITDGSTPIN LFNTAFGLLG 300
  301 MGPEGQPLGR RVASGPSPGE GISPQSAQAP QAPGDNHVVP VLR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.0
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
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