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View Structure Prediction Details

Protein: NOL6
Organism: Homo sapiens
Length: 1146 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NOL6.

Description E-value Query
Range
Subject
Range
NOL6_MOUSE - Nucleolar protein 6 OS=Mus musculus GN=Nol6 PE=2 SV=2
0.0 [1..1146] [12..1152]
gi|20988377, gi|... - gi|20988377|gb|AAH30139.1| NOL6 protein [Homo sapiens], gi|119578903|gb|EAW58499.1| nucleolar protei...
0.0 [1..1146] [1..1143]
gi|109111214 - gi|109111214|ref|XP_001099208.1| PREDICTED: similar to nucleolar RNA-associated protein alpha isofor...
0.0 [1..1146] [1..1146]
gi|34867149, gi|... - gi|34867149|ref|XP_232898.2| PREDICTED: similar to nucleolar RNA-associated protein alpha [Rattus no...
0.0 [1..1146] [1..1146]
gi|73971747 - gi|73971747|ref|XP_538704.2| PREDICTED: similar to nucleolar RNA-associated protein alpha isoform [C...
0.0 [2..1146] [145..1282]

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Predicted Domain #1
Region A:
Residues: [1-639]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGPAPAGEQL RGATGEPEVM EPALEGTGKE GKKASSRKRT LAEPPAKGLL QPVKLSRAEL  60
   61 YKEPTNEELN RLRETEILFH SSLLRLQVEE LLKEVRLSEK KKDRIDAFLR EVNQRVVRVP 120
  121 SVPETELTDQ AWLPAGVRVP LHQVPYAVKG CFRFLPPAQV TVVGSYLLGT CIRPDINVDV 180
  181 ALTMPREILQ DKDGLNQRYF RKRALYLAHL AHHLAQDPLF GSVCFSYTNG CHLKPSLLLR 240
  241 PRGKDERLVT VRLHPCPPPD FFRPCRLLPT KNNVRSAWYR GQSPAGDGSP EPPTPRYNTW 300
  301 VLQDTVLESH LQLLSTILSS AQGLKDGVAL LKVWLRQREL DKGQGGFTGF LVSMLVVFLV 360
  361 STRKIHTTMS GYQVLRSVLQ FLATTDLTVN GISLCLSSDP SLPALADFHQ AFSVVFLDSS 420
  421 GHLNLCADVT ASTYHQVQHE ARLSMMLLDS RADDGFHLLL MTPKPMIRAF DHVLHLRPLS 480
  481 RLQAACHRLK LWPELQDNGG DYVSAALGPL TTLLEQGLGA RLNLLAHSRP PVPEWDISQD 540
  541 PPKHKDSGTL TLGLLLRPEG LTSVLELGPE ADQPEAAKFR QFWGSRSELR RFQDGAIREA 600
  601 VVWEAASMSQ KRLIPHQVVT HLLALHADIP ETCVHYVGG

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.59
Match: 1q78A
Description: Crystal structure of poly(A) polymerase in complex with 3'-dATP and magnesium chloride
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 0.210126436557659 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [640-889]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLDALIQGLK ETSSTGEEAL VAAVRCYDDL SRLLWGLEGL PLTVSAVQGA HPVLRYTEVF  60
   61 PPTPVRPAFS FYETLRERSS LLPRLDKPCP AYVEPMTVVC HLEGSGQWPQ DAEAVQRVRA 120
  121 AFQLRLAELL TQQHGLQCRA TATHTDVLKD GFVFRIRVAY QREPQILKEV QSPEGMISLR 180
  181 DTAASLRLER DTRQLPLLTS ALHGLQQQHP AFSGVARLAK RWVRAQLLGE GFADESLDLV 240
  241 AAALFLHPEP 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [890-1073]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FTPPSSPQVG FLRFLFLVST FDWKNNPLFV NLNNELTVEE QVEIRSGFLA ARAQLPVMVI  60
   61 VTPQDRKNSV WTQDGPSAQI LQQLVVLAAE ALPMLEKQLM DPRGPGDIRT VFRPPLDIYD 120
  121 VLIRLSPRHI PRHRQAVDSP AASFCRGLLS QPGPSSLMPV LGYDPPQLYL TQLREAFGDL 180
  181 ALFF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [1074-1146]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YDQHGGEVIG VLWKPTSFQP QPFKASSTKG RMVMSRGGEL VMVPNVEAIL EDFAVLGEGL  60
   61 VQTVEARSER WTV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.856 0.142 condensed nuclear chromosome d.19.1 MHC antigen-recognition domain


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