YRC Public Data Repository - Protein Structure Prediction

Protein:	APH1B
Organism:	Homo sapiens
Length:	257 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for APH1B.

Description	E-value	Query Range	Subject Range
gi\|110293151, gi... - gi\|34864291\|ref\|XP_217185.2\| PREDICTED: similar to APH1B homolog (C.elegans) [Rattus norvegicus], gi...	0.0	[1..257]	[1..257]
APH1B_MOUSE - Gamma-secretase subunit APH-1B OS=Mus musculus GN=Aph1b PE=2 SV=1	0.0	[1..257]	[1..257]
gi\|67970371 - gi\|67970371\|dbj\|BAE01528.1\| unnamed protein product [Macaca fascicularis]	2.0E-99	[1..257]	[1..257]
gi\|109081433 - gi\|109081433\|ref\|XP_001105067.1\| PREDICTED: similar to presenilin stabilization factor-like [Macaca ...	2.0E-99	[1..257]	[1..257]
APH1B_PONAB - Gamma-secretase subunit APH-1B OS=Pongo abelii GN=APH1B PE=2 SV=1 APH1B_PONPY - Gamma-secretase subunit APH-1B - Pongo pygmaeus (Orangutan)	5.0E-99	[1..257]	[1..257]
gi\|37077447, gi\|... - sp\|Q8WW43\|AP1B_HUMAN Gamma-secretase subunit APH-1B (APH-1b) (Aph-1beta) (Presenilin stabilization f... gi\|117644216, gi... - gi\|117644522\|emb\|CAL37756.1\| hypothetical protein [synthetic construct], gi\|117644216\|emb\|CAL37602.1...	2.0E-98	[1..257]	[1..257]
APH1B_DANRE - Gamma-secretase subunit Aph-1b OS=Danio rerio GN=aph1b PE=2 SV=1	3.0E-93	[1..257]	[1..258]

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Predicted Domain #1

Region A:
Residues: [1-104]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAAVFFGCA FIAFGPALAL YVFTIATEPL RIIFLIAGAF FWLVSLLISS LVWFMARVII  60
   61 DNKDGPTQKY LLIFGAFVSV YIQEMFRFAY YKLLKKASEG LKSI

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [105-157]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPGETAPSMR LLAYVSGLGF GIMSGVFSFV NTLSDSLGPG TVGIHGDSPQ FFL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [158-257]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YSAFMTLVII LLHVFWGIVF FDGCEKKKWG ILLIVLLTHL LVSAQTFISS YYGINLASAF  60
   61 IILVLMGTWA FLAAGGSCRS LKLCLLCQDK NFLLYNQRSR

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits