YRC Public Data Repository - Protein Structure Prediction

Protein:	RAPSN
Organism:	Homo sapiens
Length:	412 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RAPSN.

Description	E-value	Query Range	Subject Range
gi\|186686829, gi... - gi\|53687333\|ref\|ZP_00107979.2\| COG0457: FOG: TPR repeat [Nostoc punctiforme PCC 73102], gi\|186686829...	3.0E-56	[5..396]	[125..518]
gi\|71674720, gi\|... - gi\|71674720\|ref\|ZP_00672466.1\| TPR repeat:TPR-related region [Trichodesmium erythraeum IMS101], gi\|7...	1.0E-55	[5..393]	[252..642]
gi\|50756541 - gi\|50756541\|ref\|XP_415204.1\| PREDICTED: similar to TPR repeat containing protein KIAA1043 [Gallus ga...	8.0E-55	[5..411]	[475..886]
gi\|49092446, gi\|... - gi\|67526179\|ref\|XP_661151.1\| hypothetical protein AN3547.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	1.0E-54	[1..411]	[787..1225]
gi\|109496198 - gi\|109496198\|ref\|XP_222260.4\| PREDICTED: similar to TPR repeat-containing protein KIAA1043 [Rattus n...	2.0E-54	[8..407]	[429..833]
gi\|109093703 - gi\|109093703\|ref\|XP_001108189.1\| PREDICTED: hypothetical protein LOC23331, partial [Macaca mulatta]	2.0E-54	[5..411]	[226..637]
TTC28 - tetratricopeptide repeat domain 28	2.0E-54	[3..405]	[591..1004]
gi\|114685618 - gi\|114685618\|ref\|XP_001172489.1\| PREDICTED: tetratricopeptide repeat domain 28 [Pan troglodytes]	2.0E-54	[3..405]	[591..1004]

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Predicted Domain #1

Region A:
Residues: [1-412]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGQDQTKQQI EKGLQLYQSN QTEKALQVWT KVLEKSSDLM GRFRVLGCLV TAHSEMGRYK  60
   61 EMLKFAVVQI DTARELEDAD FLLESYLNLA RSNEKLCEFH KTISYCKTCL GLPGTRAGAQ 120
  121 LGGQVSLSMG NAFLGLSVFQ KALESFEKAL RYAHNNDDAM LECRVCCSLG SFYAQVKDYE 180
  181 KALFFPCKAA ELVNNYGKGW SLKYRAMSQY HMAVAYRLLG RLGSAMECCE ESMKIALQHG 240
  241 DRPLQALCLL CFADIHRSRG DLETAFPRYD SAMSIMTEIG NRLGQVQALL GVAKCWVARK 300
  301 ALDKALDAIE RAQDLAEEVG NKLSQLKLHC LSESIYRSKG LQRELRAHVV RFHECVEETE 360
  361 LYCGLCGESI GEKNSRLQAL PCSHIFHLRC LQNNGTRSCP NCRRSSMKPG FV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	35.69897
Match:	1w3bA
Description:	The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.06634498978728	bayes_pls_golite062009
protein binding	1.60857679122674	bayes_pls_golite062009
signal transducer activity	0.945586902460441	bayes_pls_golite062009
molecular transducer activity	0.945586902460441	bayes_pls_golite062009
receptor activity	0.273696548489824	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: