YRC Public Data Repository - Protein Structure Prediction

Protein:	CERK
Organism:	Homo sapiens
Length:	537 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CERK.

Description	E-value	Query Range	Subject Range
gi\|114686947 - gi\|114686947\|ref\|XP_001137835.1\| PREDICTED: ceramide kinase isoform 1 [Pan troglodytes]	528.0	[0..1]	[537..1]
gi\|109094558 - gi\|109094558\|ref\|XP_001111087.1\| PREDICTED: similar to ceramide kinase isoform a [Macaca mulatta]	527.0	[0..1]	[537..1]
gi\|198442891, gi... - gi\|34867563\|ref\|XP_217019.2\| PREDICTED: similar to Ceramide kinase (Acylsphingosine kinase) (mCERK) ...	525.0	[0..1]	[531..1]
gi\|31542378, gi\|... - ref\|NP_663450.2\| ceramide kinase [Mus musculus], gi\|26342492\|dbj\|BAC34908.1\| unnamed protein produc...	521.0	[0..1]	[531..1]
gi\|13359167 - gi\|13359167\|dbj\|BAB33316.1\| KIAA1646 protein [Homo sapiens]	460.0	[0..57]	[537..1]
gi\|73969242 - gi\|73969242\|ref\|XP_531694.2\| PREDICTED: similar to ceramide kinase isoform a [Canis familiaris]	434.0	[0..33]	[532..21]
gi\|60098961, gi\|... - gi\|71897033\|ref\|NP_001026511.1\| ceramide kinase [Gallus gallus], gi\|60098961\|emb\|CAH65311.1\| hypothe...	398.0	[0..10]	[537..12]
gi\|49257665, gi\|... - gi\|49257665\|gb\|AAH74350.1\| MGC84197 protein [Xenopus laevis], gi\|148228496\|ref\|NP_001086227.1\| MGC84...	374.0	[0..10]	[530..12]

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Predicted Domain #1

Region A:
Residues: [1-129]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGATGAAEPL QSVLWVKQQR CAVSLEPARA LLRWWRSPGP GAGAPGADAC SVPVSEIIAV  60
   61 EETDVHGKHQ GSGKWQKMEK PYAFTVHCVK RARRHRWKWA QVTFWCPEEQ LCHLWLQTLR 120
  121 EMLEKLTSR

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.56
Match:	1maiA
Description:	STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM PHOSPHOLIPASE C DELTA IN COMPLEX WITH INOSITOL TRISPHOSPHATE
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [130-537]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKHLLVFINP FGGKGQGKRI YERKVAPLFT LASITTDIIV TEHANQAKET LYEINIDKYD  60
   61 GIVCVGGDGM FSEVLHGLIG RTQRSAGVDQ NHPRAVLVPS SLRIGIIPAG STDCVCYSTV 120
  121 GTSDAETSAL HIVVGDSLAM DVSSVHHNST LLRYSVSLLG YGFYGDIIKD SEKKRWLGLA 180
  181 RYDFSGLKTF LSHHCYEGTV SFLPAQHTVG SPRDRKPCRA GCFVCRQSKQ QLEEEQKKAL 240
  241 YGLEAAEDVE EWQVVCGKFL AINATNMSCA CRRSPRGLSP AAHLGDGSSD LILIRKCSRF 300
  301 NFLRFLIRHT NQQDQFDFTF VEVYRVKKFQ FTSKHMEDED SDLKEGGKKR FGHICSSHPS 360
  361 CCCTVSNSSW NCDGEVLHSP AIEVRVHCQL VRLFARGIEE NPKPDSHS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	41.221849
Match:	2bonA
Description:	No description for 2bonA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits