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View Structure Prediction Details

Protein: TMPO
Organism: Homo sapiens
Length: 694 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TMPO.

Description E-value Query
Range
Subject
Range
gi|885683, gi|75... - gi|885683|gb|AAB60433.1| thymopoietin alpha [Homo sapiens], pir||G01161 thymopoietin alpha - human,...
0.0 [1..694] [1..694]
gi|114646424 - gi|114646424|ref|XP_509288.2| PREDICTED: thymopoietin isoform 3 [Pan troglodytes]
0.0 [1..694] [1..694]
gi|109098344 - gi|109098344|ref|XP_001082600.1| PREDICTED: thymopoietin isoform 2 [Macaca mulatta]
0.0 [1..694] [1..695]
LAP2A_MOUSE - Lamina-associated polypeptide 2, isoforms alpha/zeta OS=Mus musculus GN=Tmpo PE=1 SV=3
0.0 [1..694] [1..693]
gi|73977640 - gi|73977640|ref|XP_539735.2| PREDICTED: similar to Lamina-associated polypeptide 2 isoform alpha (Th...
0.0 [1..693] [1..692]
gi|76618969 - gi|76618969|ref|XP_873058.1| PREDICTED: similar to thymopoietin gamma isoform 3 [Bos taurus]
0.0 [1..694] [1..689]

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Predicted Domain #1
Region A:
Residues: [1-184]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPEFLEDPSV LTKDKLKSEL VANNVTLPAG EQRKDVYVQL YLQHLTARNR PPLPAGTNSK  60
   61 GPPDFSSDEE REPTPVLGSG AAAAGRSRAA VGRKATKKTD KPRQEDKDDL DVTELTNEDL 120
  121 LDQLVKYGVN PGPIVGTTRK LYEKKLLKLR EQGTESRSST PLPTISSSAE NTRQNGSNDS 180
  181 DRYS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 65.154902
Match: 1gjjA
Description: Thymopoietin, LAP2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.63363793174066 bayes_pls_golite062009
lamin binding 1.3991011791738 bayes_pls_golite062009
protein binding 1.22727766276611 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [185-233]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNEEGKKKEH KKVKSTRDIV PFSELGTTPS GGGFFQGISF PEISTRPPL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [234-441]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSTELQAAKK VHTSKGDLPR EPLVATNLPG RGQLQKLASE RNLFISCKSS HDRCLEKSSS  60
   61 SSSQPEHSAM LVSTAASPSL IKETTTGYYK DIVENICGRE KSGIQPLCPE RSHISDQSPL 120
  121 SSKRKALEES ESSQLISPPL AQAIRDYVNS LLVQGGVGSL PGTSNSMPPL DVENIQKRID 180
  181 QSKFQETEFL SPPRKVPRLS EKSVEERD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [442-694]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGSFVAFQNI PGSELMSSFA KTVVSHSLTT LGLEVAKQSQ HDKIDASELS FPFHESILKV  60
   61 IEEEWQQVDR QLPSLACKYP VSSREATQIL SVPKVDDEIL GFISEATPLG GIQAASTESC 120
  121 NQQLDLALCR AYEAAASALQ IATHTAFVAK AMQADISQAA QILSSDPSRT HQALGILSKT 180
  181 YDAASYICEA AFDEVKMAAH TMGNATVGRR YLWLKDCKIN LASKNKLAST PFKGGTLFGG 240
  241 EVCKVIKKRG NKH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 115.0
Match: 2v0xA
Description: No description for 2v0xA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle