YRC Public Data Repository - Protein Structure Prediction

Protein:	EIF6
Organism:	Homo sapiens
Length:	245 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EIF6.

Description	E-value	Query Range	Subject Range
gi\|242247423, gi... - gi\|242247423\|ref\|NP_001156035.1\| eukaryotic translation initiation factor 6 [Ovis aries], gi\|2388150... IF6_BOVIN - Eukaryotic translation initiation factor 6 OS=Bos taurus GN=EIF6 PE=2 SV=2	0.0	[1..245]	[1..245]
gi\|61365887, gi\|... - gi\|61365887\|gb\|AAX42779.1\| integrin beta 4 binding protein [synthetic construct], gi\|54696380\|gb\|AAV...	0.0	[1..245]	[1..245]
IF6_XENLA - Eukaryotic translation initiation factor 6 OS=Xenopus laevis GN=eif6 PE=2 SV=1	0.0	[1..245]	[1..245]
gi\|74195886 - gi\|74195886\|dbj\|BAE30503.1\| unnamed protein product [Mus musculus]	0.0	[1..245]	[1..245]
gi\|57104176 - gi\|57104176\|ref\|XP_534401.1\| PREDICTED: similar to Eukaryotic translation initiation factor 6 (eIF-6...	0.0	[1..245]	[1..245]
IF6_RAT - Eukaryotic translation initiation factor 6 OS=Rattus norvegicus GN=Eif6 PE=1 SV=1	0.0	[1..245]	[1..245]
gi\|55742154 - ref\|NP_001006884.1\| integrin beta 4 binding protein [Xenopus tropicalis] gi\|55742154, gi\|... - gi\|89272061\|emb\|CAJ82882.1\| integrin beta 4 binding protein [Xenopus tropicalis], gi\|89269930\|emb\|CA...	0.0	[1..245]	[1..245]
gi\|71895027, gi\|... - gi\|71895027\|ref\|NP_001026019.1\| eukaryotic translation initiation factor 6 [Gallus gallus], gi\|53130...	0.0	[1..245]	[1..245]

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Predicted Domain #1

Region A:
Residues: [1-245]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVRASFENN CEIGCFAKLT NTYCLVAIGG SENFYSVFEG ELSDTIPVVH ASIAGCRIIG  60
   61 RMCVGNRHGL LVPNNTTDQE LQHIRNSLPD TVQIRRVEER LSALGNVTTC NDYVALVHPD 120
  121 LDRETEEILA DVLKVEVFRQ TVADQVLVGS YCVFSNQGGL VHPKTSIEDQ DELSSLLQVP 180
  181 LVAGTVNRGS EVIAAGMVVN DWCAFCGLDT TSTELSVVES VFKLNEAQPS TIATSMRDSL 240
  241 IDSLT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	103.0
Match:	1g62A
Description:	Ribosome anti-association factor eIF6 (aIF6)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
translation initiation factor activity	2.82313826209658	bayes_pls_golite062009
ribosomal large subunit binding	2.29551693750603	bayes_pls_golite062009
binding	1.48640777619976	bayes_pls_golite062009
nucleic acid binding	1.14138534491569	bayes_pls_golite062009
hydrolase activity	1.05437300113124	bayes_pls_golite062009
catalytic activity	0.889920589881492	bayes_pls_golite062009
protein binding	0.21271994410782	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: