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View Structure Prediction Details

Protein: KLHDC4
Organism: Homo sapiens
Length: 520 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KLHDC4.

Description E-value Query
Range		 Subject
Range
gi|10436213 - gi|10436213|dbj|BAB14756.1| unnamed protein product [Homo sapiens]
 0.0 [14..520] [14..520]
gi|114664006, gi... - gi|114664006|ref|XP_001157288.1| PREDICTED: kelch domain containing 4 isoform 5 [Pan troglodytes], g...
 2.0E-99 [14..517] [14..516]
KLDC4_PONPY - Kelch domain-containing protein 4 - Pongo pygmaeus (Orangutan)
KLDC4_PONAB - Kelch domain-containing protein 4 OS=Pongo abelii GN=KLHDC4 PE=2 SV=1
 1.0E-97 [14..487] [14..487]
gi|109129458 - gi|109129458|ref|XP_001086874.1| PREDICTED: similar to kelch domain containing 4 [Macaca mulatta]
 2.0E-96 [14..487] [14..487]
KLDC4_MOUSE - Kelch domain-containing protein 4 OS=Mus musculus GN=Klhdc4 PE=2 SV=2
 7.0E-96 [14..487] [14..487]
gi|149038370, gi... - gi|149038370|gb|EDL92730.1| rCG51065, isoform CRA_a [Rattus norvegicus], gi|109509005|ref|XP_0010791...
 9.0E-96 [14..519] [14..522]
gi|73956945 - gi|73956945|ref|XP_546788.2| PREDICTED: similar to kelch domain containing 4 [Canis familiaris]
 8.0E-94 [14..518] [123..626]
gi|12698095 - gi|12698095|dbj|BAB21874.1| hypothetical protein [Macaca fascicularis]
 9.0E-93 [35..487] [14..466]
gi|76666345 - gi|76666345|ref|XP_869770.1| PREDICTED: similar to kelch domain containing 4 isoform 2 [Bos taurus]
 1.0E-92 [14..496] [14..496]

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Predicted Domain #1
Region A:
Residues: [1-353] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKKGKKEKK GRGAEKTAAK MEKKVSKRSR KEEEDLEALI AHFQTLDAKR TQTVELPCPP  60
   61 PSPRLNASLS VHPEKDELIL FGGEYFNGQK TFLYNELYVY NTRKDTWTKV DIPSPPPRRC 120
  121 AHQAVVVPQG GGQLWVFGGE FASPNGEQFY HYKDLWVLHL ATKTWEQVKS TGGPSGRSGH 180
  181 RMVAWKRQLI LFGGFHESTR DYIYYNDVYA FNLDTFTWSK LSPSGTGPTP RSGCQMSVTP 240
  241 QGGIVVYGGY SKQRVKKDVD KGTRHSDMFL LKPEDGREDK WVWTRMNPSG VKPTPRSGFS 300
  301 VAMAPNHQTL FFGGVCDEEE EESLSGEFFN DLYFYDATRN RWFEGQLKGP KSE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.522879
Match: 1x2jA
Description: Structural basis for the defects of human lung cancer somatic mutations in the repression activity of Keap1 on Nrf2
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [354-520] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKKRRRGRKE EPEGGSRPAC GGAGTQGPVQ LVKEVVAEDG TVVTIKQVLT APGSAGQPRS  60
   61 EDEDSLEEAG SPAPGPCPRS NAMLAVKHGV LYVYGGMFEA GDRQVTLSDL HCLDLHRMEA 120
  121 WKALVEMDPE TQEWLEETDS EEDSEEVEGA EGGVDDEDSG EESGAED

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.63
Match: 2dyhA
Description: No description for 2dyhA was found.
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