YRC Public Data Repository - Protein Structure Prediction

Protein:	FGF6
Organism:	Homo sapiens
Length:	208 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FGF6.

Description	E-value	Query Range	Subject Range
gi\|114642913 - gi\|114642913\|ref\|XP_001157123.1\| PREDICTED: fibroblast growth factor 6 [Pan troglodytes]	4.0E-64	[1..208]	[1..208]
gi\|109095116 - gi\|109095116\|ref\|XP_001099809.1\| PREDICTED: fibroblast growth factor 6 [Macaca mulatta]	9.0E-64	[1..208]	[1..208]
gi\|57107089 - gi\|57107089\|ref\|XP_543862.1\| PREDICTED: similar to fibroblast growth factor 6 isoform 1 [Canis famil...	2.0E-63	[1..208]	[1..208]
gi\|149049365, gi... - gi\|18777759\|ref\|NP_571983.1\| fibroblast growth factor 6 [Rattus norvegicus], gi\|18652949\|dbj\|BAB8470...	4.0E-63	[1..208]	[1..208]
gi\|147898157, gi... - gi\|147898157\|gb\|AAI40269.1\| Fibroblast growth factor 6 [synthetic construct], gi\|146327707\|gb\|AAI416... FGF6_MOUSE - Fibroblast growth factor 6 OS=Mus musculus GN=Fgf6 PE=2 SV=2	5.0E-63	[1..208]	[1..208]
gi\|56417377 - gi\|56417377\|gb\|AAV90630.1\| FGF6 [Dicentrarchus labrax]	4.0E-62	[1..208]	[1..209]
gi\|3980190 - gi\|3980190\|emb\|CAA76422.1\| fibroblast growth factor 6-related protein [Oncorhynchus mykiss]	8.0E-62	[1..208]	[1..206]
gi\|61835668 - gi\|61835668\|ref\|XP_593127.1\| PREDICTED: similar to fibroblast growth factor [Bos taurus]	4.0E-61	[1..208]	[1..208]
gi\|84798489, gi\|... - gi\|89191828\|ref\|NP_001001398.2\| fibroblast growth factor 6a [Danio rerio], gi\|84798489\|gb\|ABC67200.1...	4.0E-60	[1..208]	[1..205]

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Predicted Domain #1

Region A:
Residues: [1-208]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALGQKLFIT MSRGAGRLQG TLWALVFLGI LVGMVVPSPA GTRANNTLLD SRGWGTLLSR  60
   61 SRAGLAGEIA GVNWESGYLV GIKRQRRLYC NVGIGFHLQV LPDGRISGTH EENPYSLLEI 120
  121 STVERGVVSL FGVRSALFVA MNSKGRLYAT PSFQEECKFR ETLLPNNYNA YESDLYQGTY 180
  181 IALSKYGRVK RGSKVSPIMT VTHFLPRI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	44.09691
Match:	1ijtA
Description:	Fibroblast growth factor 4 (FGF4)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
fibroblast growth factor receptor binding	5.68976822724664	bayes_pls_golite062009
growth factor activity	5.6790632853895	bayes_pls_golite062009
receptor binding	4.8109037277027	bayes_pls_golite062009
cytokine activity	3.76931834545338	bayes_pls_golite062009
protein binding	2.99442649109752	bayes_pls_golite062009
glycosaminoglycan binding	2.49177421879896	bayes_pls_golite062009
binding	2.26121569090272	bayes_pls_golite062009
heparin binding	2.1616134585534	bayes_pls_golite062009
polysaccharide binding	1.81686028727894	bayes_pls_golite062009
signal transducer activity	1.16870777190189	bayes_pls_golite062009
molecular transducer activity	1.16870777190189	bayes_pls_golite062009
pattern binding	0.839280621598109	bayes_pls_golite062009
interleukin-1 receptor binding	0.8084616632765	bayes_pls_golite062009
nerve growth factor receptor binding	0.308245352535379	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: