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View Structure Prediction Details

Protein: NMNAT3
Organism: Homo sapiens
Length: 252 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NMNAT3.

Description E-value Query
Range
Subject
Range
gi|109049061 - gi|109049061|ref|XP_001113442.1| PREDICTED: nicotinamide nucleotide adenylyltransferase 3 isoform 5 ...
259.0 [0..1] [252..1]
NMNAT3 - nicotinamide nucleotide adenylyltransferase 3
h0018512 - null
256.0 [0..1] [252..1]
gi|73990640 - gi|73990640|ref|XP_534286.2| PREDICTED: similar to Nicotinamide mononucleotide adenylyltransferase 3...
255.0 [0..1] [252..34]
gi|114589488, gi... - gi|114589490|ref|XP_516785.2| PREDICTED: nicotinamide nucleotide adenylyltransferase 3 isoform 7 [Pa...
254.0 [0..1] [251..1]
NMNA3_MOUSE - Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 OS=Mus musculus GN=Nmnat3 PE=1 SV=1
234.0 [0..1] [242..1]

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Predicted Domain #1
Region A:
Residues: [1-252]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSRIPVVLL ACGSFNPITN MHLRMFEVAR DHLHQTGMYQ VIQGIISPVN DTYGKKDLAA  60
   61 SHHRVAMARL ALQTSDWIRV DPWESEQAQW METVKVLRHH HSKLLRSPPQ MEGPDHGKAL 120
  121 FSTPAAVPEL KLLCGADVLK TFQTPNLWKD AHIQEIVEKF GLVCVGRVSH DPKGYIAESP 180
  181 ILRMHQHNIH LAKEPVQNEI SATYIRRALG QGQSVKYLIP DAVITYIKDH GLYTKGSTWK 240
  241 GKSTQSTEGK TS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 67.522879
Match: 1nupA
Description: Cytosolic NMN/NAMN adenylyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nicotinate-nucleotide adenylyltransferase activity 2.94996967804011 bayes_pls_golite062009
nicotinamide-nucleotide adenylyltransferase activity 2.8149071156304 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 2.54008423253828 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 2.54008423253828 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 2.52910114154477 bayes_pls_golite062009
catalytic activity 2.37674226834122 bayes_pls_golite062009
ligase activity 1.92894388839884 bayes_pls_golite062009
binding 1.11291710031577 bayes_pls_golite062009
adenylyltransferase activity 1.08055019963499 bayes_pls_golite062009
nucleic acid binding 0.623161608923414 bayes_pls_golite062009
nucleotidyltransferase activity 0.564359271862248 bayes_pls_golite062009
pantetheine-phosphate adenylyltransferase activity 0.454904507512502 bayes_pls_golite062009
pantoate-beta-alanine ligase activity 0.282286652169846 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle