YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|41327754
Organism:	Homo sapiens
Length:	784 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|41327754.

Description	E-value	Query Range	Subject Range
gi\|83405567, gi\|... - gi\|83405567\|gb\|AAI10619.1\| Receptor-interacting serine-threonine kinase 4 [Homo sapiens], gi\|8340515...	448.0	[0..1]	[784..1]
gi\|34868038, gi\|... - ref\|XP_221619.2\| similar to PKC-regulated kinase PKK [Rattus norvegicus], gi\|109493006\|ref\|XP_221619...	445.0	[0..1]	[773..1]
RIPK4_MOUSE - Receptor-interacting serine/threonine-protein kinase 4 OS=Mus musculus GN=Ripk4 PE=1 SV=2	442.0	[0..1]	[773..1]
gi\|76608333 - gi\|76608333\|ref\|XP_880279.1\| PREDICTED: similar to ankyrin repeat domain 3 isoform 4 [Bos taurus]	434.0	[0..1]	[784..1]
gi\|50760226 - gi\|50760226\|ref\|XP_425812.1\| PREDICTED: similar to neural cell adhesion molecule long domain form pr...	419.0	[0..13]	[783..3788]
gi\|108868779, gi... - gi\|157106769\|ref\|XP_001649474.1\| ankyrin 2,3/unc44 [Aedes aegypti], gi\|108868779\|gb\|EAT33004.1\| anky...	363.0	[0..387]	[783..1]
gi\|115610200 - gi\|115610200\|ref\|XP_790283.2\| PREDICTED: similar to ankyrin 2,3/unc44, partial [Strongylocentrotus p...	360.0	[0..402]	[782..1527]

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Predicted Domain #1

Region A:
Residues: [1-297]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGDGGTPWA LALLRTFDAG EFTGWEKVGS GGFGQVYKVR HVHWKTWLAI KCSPSLHVDD  60
   61 RERMELLEEA KKMEMAKFRY ILPVYGICRE PVGLVMEYME TGSLEKLLAS EPLPWDLRFR 120
  121 IIHETAVGMN FLHCMAPPLL HLDLKPANIL LDAHYHVKIS DFGLAKCNGL SHSHDLSMDG 180
  181 LFGTIAYLPP ERIREKSRLF DTKHDVYSFA IVIWGVLTQK KPFADEKNIL HIMVKVVKGH 240
  241 RPELPPVCRA RPRACSHLIR LMQRCWQGDP RVRPTFQEIT SETEDLCEKP DDEVKET

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	33.221849
Match:	1muoA
Description:	Aurora-related kinase 1 (aurora-2)
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [298-436]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AHDLDVKSPP EPRSEVVPAR LKRASAPTFD NDYSLSELLS QLDSGVSQAV EGPEELSRSS  60
   61 SESKLPSSGS GKRLSGVSSV DSAFSSRGSL SLSFEREPST SDLGTTDVQK KKLVDAIVSG 120
  121 DTSKLMKILQ PQDVDLALD

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.237	a.24.9	alpha-catenin/vinculin
View	Download	0.227	d.124.1	Ribonuclease Rh-like

Predicted Domain #3

Region A:
Residues: [437-784]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGASLLHLAV EAGQEECAKW LLLNNANPNL SNRRGSTPLH MAVERRVRGV VELLLARKIS  60
   61 VNAKDEDQWT ALHFAAQNGD ESSTRLLLEK NASVNEVDFE GRTPMHVACQ HGQENIVRIL 120
  121 LRRGVDVSLQ GKDAWLPLHY AAWQGHLPIV KLLAKQPGVS VNAQTLDGRT PLHLAAQRGH 180
  181 YRVARILIDL CSDVNVCSLL AQTPLHVAAE TGHTSTARLL LHRGAGKEAM TSDGYTALHL 240
  241 AARNGHLATV KLLVEEKADV LARGPLNQTA LHLAAAHGHS EVVEELVSAD VIDLFDEQGL 300
  301 SALHLAAQGR HAQTVETLLR HGAHINLQSL KFQGGHGPAA TLLRRSKT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	86.154902
Match:	1n11A
Description:	Ankyrin-R
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits