YRC Public Data Repository - Protein Structure Prediction

Protein:	HMGCS2
Organism:	Homo sapiens
Length:	508 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HMGCS2.

Description	E-value	Query Range	Subject Range
gi\|149030530, gi... - gi\|54035469\|gb\|AAH83543.1\| 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) [Rattus ...	0.0	[1..508]	[1..508]
HMCS2_MOUSE - Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Mus musculus GN=Hmgcs2 PE=1 SV=2	0.0	[1..508]	[1..508]
gi\|55587844 - gi\|55587844\|ref\|XP_513693.1\| PREDICTED: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondr...	0.0	[1..508]	[1..508]
gi\|48145817 - gi\|48145817\|emb\|CAG33131.1\| HMGCS2 [Homo sapiens]	0.0	[1..508]	[1..508]
gi\|109014698 - gi\|109014698\|ref\|XP_001114146.1\| PREDICTED: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitoch...	0.0	[1..508]	[1..508]
HMCS2_PIG - Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Sus scrofa GN=HMGCS2 PE=2 SV=1	0.0	[1..508]	[1..508]
HMCS2_BOVIN - Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Bos taurus GN=HMGCS2 PE=1 SV=1	0.0	[1..508]	[1..508]

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Predicted Domain #1

Region A:
Residues: [1-508]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQRLLTPVKR ILQLTRAVQE TSLTPARLLP VAHQRFSTAS AVPLAKTDTW PKDVGILALE  60
   61 VYFPAQYVDQ TDLEKYNNVE AGKYTVGLGQ TRMGFCSVQE DINSLCLTVV QRLMERIQLP 120
  121 WDSVGRLEVG TETIIDKSKA VKTVLMELFQ DSGNTDIEGI DTTNACYGGT ASLFNAANWM 180
  181 ESSSWDGRYA MVVCGDIAVY PSGNARPTGG AGAVAMLIGP KAPLALERGL RGTHMENVYD 240
  241 FYKPNLASEY PIVDGKLSIQ CYLRALDRCY TSYRKKIQNQ WKQAGSDRPF TLDDLQYMIF 300
  301 HTPFCKMVQK SLARLMFNDF LSASSDTQTS LYKGLEAFGG LKLEDTYTNK DLDKALLKAS 360
  361 QDMFDKKTKA SLYLSTHNGN MYTSSLYGCL ASLLSHHSAQ ELAGSRIGAF SYGSGLAASF 420
  421 FSFRVSQDAA PGSPLDKLVS STSDLPKRLA SRKCVSPEEF TEIMNQREQF YHKVNFSPPG 480
  481 DTNSLFPGTW YLERVDEQHR RKYARRPV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	109.0
Match:	2p8uA
Description:	No description for 2p8uA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits