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View Structure Prediction Details

Protein: PGRMC2
Organism: Homo sapiens
Length: 223 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PGRMC2.

Description E-value Query
Range
Subject
Range
gi|114595991 - gi|114595991|ref|XP_517434.2| PREDICTED: similar to progresterone binding protein [Pan troglodytes]
5.0E-63 [1..223] [25..247]
PGRC2_MOUSE - Membrane-associated progesterone receptor component 2 OS=Mus musculus GN=Pgrmc2 PE=1 SV=2
5.0E-62 [1..223] [1..217]
PGRC2_RAT - Membrane-associated progesterone receptor component 2 OS=Rattus norvegicus GN=Pgrmc2 PE=1 SV=1
5.0E-62 [1..223] [1..217]
gi|61859954 - gi|61859954|ref|XP_613630.1| PREDICTED: similar to progesterone membrane binding protein [Bos taurus...
6.0E-62 [1..223] [25..247]
gi|109075624 - gi|109075624|ref|XP_001082791.1| PREDICTED: similar to progesterone membrane binding protein [Macaca...
2.0E-59 [1..223] [25..247]
gi|57100531 - gi|57100531|ref|XP_533292.1| PREDICTED: similar to progesterone membrane binding protein [Canis fami...
4.0E-59 [1..223] [1..223]
gi|49904307 - gi|49904307|gb|AAH77054.1| Pgrmc2 protein [Xenopus tropicalis]
4.0E-58 [1..223] [57..262]
gi|185134138, gi... - gi|25046107|gb|AAL49963.1| progestin membrane receptor component 1 [Oncorhynchus mykiss], gi|1851341...
3.0E-50 [52..222] [15..181]

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Predicted Domain #1
Region A:
Residues: [1-78]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAGDGDVKL GTLGSGSESS NDGGSESPGD AGAAAEGGGW AAAALALLTG GGEMLLNVAL  60
   61 VALVLLGAYR LWVRWGRR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [79-223]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLGAGAGAGE ESPATSLPRM KKRDFSLEQL RQYDGSRNPR ILLAVNGKVF DVTKGSKFYG  60
   61 PAGPYGIFAG RDASRGLATF CLDKDALRDE YDDLSDLNAV QMESVREWEM QFKEKYDYVG 120
  121 RLLKPGEEPS EYTDEEDTKD HNKQD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.045757
Match: 1t0gA
Description: Hypothetical protein At2g24940.1 from Arabidopsis thaliana has a cytochrome b5 like fold
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle