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View Structure Prediction Details

Protein: SPT14
Organism: Saccharomyces cerevisiae
Length: 461 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPT14.

Description E-value Query
Range
Subject
Range
SPT14 - UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosp...
0.0 [1..461] [1..461]
gi|38327651, gi|... - gi|38327651|ref|NP_035211.1| phosphatidylinositol glycan, class A [Mus musculus], gi|26328103|dbj|BA...
0.0 [12..461] [33..484]
PIGA - phosphatidylinositol glycan anchor biosynthesis, class A
0.0 [10..461] [31..483]
gi|28919533, gi|... - gi|32419927|ref|XP_330407.1| hypothetical protein [Neurospora crassa], gi|28919533|gb|EAA28961.1| ph...
gi|85089974 - gi|85089974|ref|XP_958197.1| phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit [Neur...
0.0 [13..457] [6..511]
GPI3_SCHPO - Phosphatidylinositol N-acetylglucosaminyltransferase gpi3 subunit OS=Schizosaccharomyces pombe (stra...
gpi3 - pig-A
3.0E-98 [16..445] [1..419]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
1.0E-96 [16..429] [1..414]
gi|18407913, gi|... - gi|30692535|ref|NP_850658.1| SETH2; transferase, transferring glycosyl groups [Arabidopsis thaliana]...
3.0E-96 [8..445] [3..427]
CE03109 - phosphatidylinositol biosynthetic protein status:Partially_confirmed UniProt:Q18993 protein_id:CAA91...
2.0E-94 [11..454] [7..432]
gi|8571458 - gi|8571458|gb|AAF76891.1| PIG-A [Paramecium tetraurelia]
4.0E-94 [13..440] [3..418]

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Predicted Domain #1
Region A:
Residues: [1-185]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSHKVESY NNENRMLCDF FYPQLGGVEF HIYHLSQKLI DLGHSVVIIT HAYKDRVGVR  60
   61 HLTNGLKVYH VPFFVIFRET TFPTVFSTFP IIRNILLREQ IQIVHSHGSA STFAHEGILH 120
  121 ANTMGLRTVF TDHSLYGFNN LTSIWVNKLL TFTLTNIDRV ICVSNTCKEN MIVRTELSPD 180
  181 IISVI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.69897
Match: 1f0kA_
Description: Peptidoglycan biosynthesys glycosyltransferase MurG
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [186-313]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNAVVSEDFK PRDPTGGTKR KQSRDKIVIV VIGRLFPNKG SDLLTRIIPK VCSSHEDVEF  60
   61 IVAGDGPKFI DFQQMIESHR LQKRVQLLGS VPHEKVRDVL CQGDIYLHAS LTEAFGTILV 120
  121 EAASCNLL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.69897
Match: 1f0kA_
Description: Peptidoglycan biosynthesys glycosyltransferase MurG
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [314-461]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IVTTQVGGIP EVLPNEMTVY AEQTSVSDLV QATNKAINII RSKALDTSSF HDSVSKMYDW  60
   61 MDVAKRTVEI YTNISSTSSA DDKDWMKMVA NLYKRDGIWA KHLYLLCGIV EYMLFFLLEW 120
  121 LYPRDEIDLA PKWPKKTVSN ETKEARET

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.752 0.211 transferase activity, transferring hexosyl groups a.1.1 Globin-like
View Download 0.617 0.025 transferase activity, transferring hexosyl groups a.74.1 Cyclin-like
View Download 0.615 0.002 transferase activity, transferring hexosyl groups a.72.1 Functional domain of the splicing factor Prp18
View Download 0.710 N/A N/A a.1.1 Globin-like
View Download 0.586 N/A N/A a.1.1 Globin-like
View Download 0.581 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.559 N/A N/A d.79.2 Tubulin/Dihydroxyacetone kinase C-terminal domain
View Download 0.533 N/A N/A d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.503 N/A N/A a.1.1 Globin-like
View Download 0.447 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.439 N/A N/A f.1.1 Colicin
View Download 0.390 N/A N/A a.1.1 Globin-like
View Download 0.380 N/A N/A a.1.1 Globin-like
View Download 0.378 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.363 N/A N/A d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.361 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.341 N/A N/A d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like
View Download 0.341 N/A N/A c.55.1 Actin-like ATPase domain
View Download 0.340 N/A N/A b.40.4 Nucleic acid-binding proteins
View Download 0.334 N/A N/A a.133.1 Phospholipase A2, PLA2
View Download 0.332 N/A N/A a.4.1 Homeodomain-like
View Download 0.311 N/A N/A a.1.1 Globin-like
View Download 0.305 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.285 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.283 N/A N/A d.95.2 Homing endonucleases
View Download 0.281 N/A N/A c.50.1 Macro domain-like
View Download 0.280 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.278 N/A N/A a.60.10 Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View Download 0.277 N/A N/A a.22.1 Histone-fold
View Download 0.275 N/A N/A a.74.1 Cyclin-like
View Download 0.272 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.266 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.256 N/A N/A d.163.1 DNA breaking-rejoining enzymes
View Download 0.254 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.252 N/A N/A a.146.1 Telomeric repeat binding factor (TRF) dimerisation domain
View Download 0.242 N/A N/A a.74.1 Cyclin-like
View Download 0.242 N/A N/A a.118.11 Cytochrome c oxidase subunit E
View Download 0.235 N/A N/A d.54.1 Enolase N-terminal domain-like
View Download 0.233 N/A N/A a.4.3 ARID-like
View Download 0.222 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.213 N/A N/A c.50.1 Macro domain-like
View Download 0.213 N/A N/A a.1.1 Globin-like
View Download 0.204 N/A N/A a.47.2 t-snare proteins


YRC Informatics Platform - Version 3.0
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