YRC Public Data Repository - Protein Structure Prediction

Protein:	PPT2
Organism:	Saccharomyces cerevisiae
Length:	173 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PPT2.

Description	E-value	Query Range	Subject Range
PPT2 - Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p... PPT2_YEAST - Mitochondrial holo-[acyl-carrier-protein] synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 /...	2.0E-39	[1..173]	[1..173]
ACPS_VIBPA - Holo-[acyl-carrier-protein] synthase OS=Vibrio parahaemolyticus GN=acpS PE=3 SV=1 gi\|153839831, gi... - gi\|153839831\|ref\|ZP_01992498.1\| holo-(acyl-carrier-protein) synthase [Vibrio parahaemolyticus AQ3810... ACPS_VIBPA - Holo-[acyl-carrier-protein] synthase OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)...	4.0E-28	[10..171]	[1..126]
gi\|25526775 - gi\|25526775\|pir\|\|AC3413 holo-[acyl-carrier protein] synthase (EC 2.7.8.7) [imported] - Brucella meli... gi\|17987572, gi\|... - gi\|17987572\|ref\|NP_540206.1\| 4'-phosphopantetheinyl transferase [Brucella melitensis 16M], gi\|179832...	7.0E-28	[12..170]	[59..185]
ACPS_RHIME - Holo-[acyl-carrier-protein] synthase OS=Rhizobium meliloti GN=acpS PE=3 SV=1 ACPS_RHIME - Holo-[acyl-carrier-protein] synthase OS=Rhizobium meliloti (strain 1021) GN=acpS PE=3 SV=1	3.0E-27	[12..170]	[2..128]
ACPS_VIBCH - Holo-[acyl-carrier-protein] synthase OS=Vibrio cholerae GN=acpS PE=1 SV=1 ACPS_VIBCM - Holo-[acyl-carrier-protein] synthase OS=Vibrio cholerae serotype O1 (strain M66-2) GN=acpS PE=3 SV=1 gi\|229507483, gi... - gi\|229507483\|ref\|ZP_04396988.1\| holo-[acyl-carrier protein] synthase [Vibrio cholerae BX 330286], gi... gi\|229512322, gi... - gi\|229512322\|ref\|ZP_04401801.1\| holo-[acyl-carrier protein] synthase [Vibrio cholerae B33], gi\|22935... gi\|229514083, gi... - gi\|229514083\|ref\|ZP_04403545.1\| holo-[acyl-carrier protein] synthase [Vibrio cholerae TMA 21], gi\|22... gi\|229344147, gi... - gi\|229519458\|ref\|ZP_04408901.1\| holo-[acyl-carrier protein] synthase [Vibrio cholerae RC9], gi\|22934... gi\|229606988, gi... - gi\|229606988\|ref\|YP_002877636.1\| holo-[acyl-carrier protein] synthase [Vibrio cholerae MJ-1236], gi\|... gi\|153830870, gi... - gi\|153830870\|ref\|ZP_01983537.1\| holo-(acyl-carrier-protein) synthase [Vibrio cholerae 623-39], gi\|14... gi\|149739263, gi... - gi\|153826900\|ref\|ZP_01979567.1\| holo-(acyl-carrier-protein) synthase [Vibrio cholerae MZO-2], gi\|149... gi\|121590990, gi... - gi\|121590990\|ref\|ZP_01678309.1\| holo-(acyl-carrier-protein) synthase [Vibrio cholerae 2740-80], gi\|1... gi\|153214508, gi... - gi\|153214508\|ref\|ZP_01949417.1\| holo-(acyl-carrier-protein) synthase [Vibrio cholerae 1587], gi\|1241... gi\|153222469, gi... - gi\|153222469\|ref\|ZP_01953203.1\| holo-(acyl-carrier-protein) synthase [Vibrio cholerae MAK 757], gi\|1... ACPS_VIBCH - Holo-[acyl-carrier-protein] synthase OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inab... gi\|153819823, gi... - gi\|153819823\|ref\|ZP_01972490.1\| holo-(acyl-carrier-protein) synthase [Vibrio cholerae NCTC 8457], gi... gi\|254845287, gi... - gi\|75829318\|ref\|ZP_00758625.1\| COG0736: Phosphopantetheinyl transferase (holo-ACP synthase) [Vibrio ... gi\|225355074, gi... - gi\|75818653\|ref\|ZP_00748789.1\| COG0736: Phosphopantetheinyl transferase (holo-ACP synthase) [Vibrio ...	5.0E-27	[12..172]	[2..126]
ACPS_GEOSL - Holo-[acyl-carrier-protein] synthase OS=Geobacter sulfurreducens GN=acpS PE=3 SV=1 ACPS_GEOSL - Holo-[acyl-carrier-protein] synthase OS=Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PC...	6.0E-27	[12..171]	[2..125]
ACPS_PARUW - Holo-[acyl-carrier-protein] synthase OS=Protochlamydia amoebophila (strain UWE25) GN=acpS PE=3 SV=1	1.0E-26	[13..168]	[3..119]
ACPS_BRUME - Holo-[acyl-carrier-protein] synthase OS=Brucella melitensis GN=acpS PE=3 SV=1 gi\|254717156 - gi\|254717156\|ref\|ZP_05178967.1\| 4'-phosphopantetheinyl transferase [Brucella ceti M13/05/1] gi\|254729966 - gi\|254729966\|ref\|ZP_05188544.1\| 4'-phosphopantetheinyl transferase [Brucella abortus bv. 4 str. 292] ACPS_BRUME - Holo-[acyl-carrier-protein] synthase OS=Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCT... gi\|254709785 - gi\|254709785\|ref\|ZP_05171596.1\| 4'-phosphopantetheinyl transferase [Brucella pinnipedialis B2/94] gi\|254713787 - gi\|254713787\|ref\|ZP_05175598.1\| 4'-phosphopantetheinyl transferase [Brucella ceti M644/93/1] ACPS_BRUO2 - Holo-[acyl-carrier-protein] synthase OS=Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512) GN=a... ACPS_BRUSI - Holo-[acyl-carrier-protein] synthase OS=Brucella suis (strain ATCC 23445 / NCTC 10510) GN=acpS PE=3 ... ACPS_BRUA2 - Holo-[acyl-carrier-protein] synthase OS=Brucella abortus (strain 2308) GN=acpS PE=3 SV=1 ACPS_BRUC2 - Holo-[acyl-carrier-protein] synthase OS=Brucella canis (strain ATCC 23365 / NCTC 10854) GN=acpS PE=3... ACPS_BRUAB - Holo-[acyl-carrier-protein] synthase OS=Brucella abortus biovar 1 (strain 9-941) GN=acpS PE=3 SV=1 ACPS_BRUAB - Holo-[acyl-carrier-protein] synthase OS=Brucella abortus GN=acpS PE=3 SV=1 ACPS_BRUSU - Holo-[acyl-carrier-protein] synthase OS=Brucella suis GN=acpS PE=3 SV=1 ACPS_BRUSU - Holo-[acyl-carrier-protein] synthase OS=Brucella suis biovar 1 (strain 1330) GN=acpS PE=3 SV=1 gi\|225627160, gi... - gi\|225627160\|ref\|ZP_03785198.1\| holo-acyl-carrier-protein synthase [Brucella ceti str. Cudo], gi\|225... gi\|254688935 - gi\|254688935\|ref\|ZP_05152189.1\| 4'-phosphopantetheinyl transferase [Brucella abortus bv. 6 str. 870] gi\|254693417 - gi\|254693417\|ref\|ZP_05155245.1\| 4'-phosphopantetheinyl transferase [Brucella abortus bv. 3 str. Tuly... ACPS_BRUMB - Holo-[acyl-carrier-protein] synthase OS=Brucella melitensis biotype 2 (strain ATCC 23457) GN=acpS PE... gi\|237815114, gi... - gi\|237815114\|ref\|ZP_04594112.1\| holo-(acyl-carrier-protein) synthase [Brucella abortus str. 2308 A],... gi\|254703993 - gi\|254703993\|ref\|ZP_05165821.1\| 4'-phosphopantetheinyl transferase [Brucella suis bv. 3 str. 686] ACPS_BRUA1 - Holo-[acyl-carrier-protein] synthase OS=Brucella abortus (strain S19) GN=acpS PE=3 SV=1 gi\|254707633 - gi\|254707633\|ref\|ZP_05169461.1\| 4'-phosphopantetheinyl transferase [Brucella pinnipedialis M163/99/1... gi\|254697070 - gi\|254697070\|ref\|ZP_05158898.1\| 4'-phosphopantetheinyl transferase [Brucella abortus bv. 2 str. 86/8... gi\|254701447 - gi\|254701447\|ref\|ZP_05163275.1\| 4'-phosphopantetheinyl transferase [Brucella suis bv. 5 str. 513]	1.0E-26	[12..170]	[2..128]
gi\|25304187, gi\|... - pir\|\|AH2703 holo-(acyl-carrier Protein) synthase [imported] - Agrobacterium tumefaciens (strain C58,... ACPS_AGRFC - Holo-[acyl-carrier-protein] synthase OS=Agrobacterium fabrum (strain C58 / ATCC 33970) GN=acpS PE=3 ...	2.0E-26	[12..170]	[2..128]
gi\|2528882 - gi\|2528882\|emb\|CAA75358.1\| phosphopantethiene protein transferase, Ppt1p [Corynebacterium ammoniagen...	3.0E-26	[9..169]	[4..149]

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Predicted Domain #1

Region A:
Residues: [1-173]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFASRNIGR KIAGVGVDIV YLPRFAHILE KYSPFDPCGR STLNKITRKF MHEKERFHFS  60
   61 NLLIEENCLT PRLHEYIAGV WALKECSLKA LCCCVSKHDL PPAQVLYAGM LYKTQTDTGV 120
  121 PQLEFDKMFG KKYPKYQQLS KNYDSLFSTH EFLVSLSHDK DYLIAVTNLV ERE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	24.30103
Match:	1f7tA_
Description:	Holo-(acyl carrier protein) synthase ACPS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transferase activity, transferring phosphorus-containing groups	2.72938266588109	bayes_pls_golite062009
transferase activity	1.7559537029779	bayes_pls_golite062009
catalytic activity	1.48339787978627	bayes_pls_golite062009
holo-[acyl-carrier-protein] synthase activity	0.365142654382572	bayes_pls_golite062009
phosphotransferase activity, for other substituted phosphate groups	0.203989443539086	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: