YRC Public Data Repository - Protein Structure Prediction

Protein:	COQ3
Organism:	Saccharomyces cerevisiae
Length:	312 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for COQ3.

Description	E-value	Query Range	Subject Range
COQ3 - O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynth...	3.0E-52	[1..312]	[5..316]
gi\|45187988, gi\|... - gi\|45187988\|ref\|NP_984211.1\| ADR115Wp [Ashbya gossypii ATCC 10895], gi\|44982805\|gb\|AAS52035.1\| ADR11... gi\|44982805 - gi\|44982805\|gb\|AAS52035.1\| ADR115Wp [Ashbya gossypii ATCC 10895]	3.0E-43	[13..310]	[16..311]
UBIG_COXBU - Ubiquinone biosynthesis O-methyltransferase OS=Coxiella burnetii (strain RSA 493 / Nine Mile phase I... UBIG_COXB2 - Ubiquinone biosynthesis O-methyltransferase OS=Coxiella burnetii (strain CbuG_Q212) GN=ubiG PE=3 SV=... UBIG_COXBR - Ubiquinone biosynthesis O-methyltransferase OS=Coxiella burnetii (strain RSA 331 / Henzerling II) GN... UBIG_COXBU - 3-demethylubiquinone-9 3-methyltransferase OS=Coxiella burnetii GN=ubiG PE=3 SV=1	6.0E-39	[32..308]	[4..231]
UBIG_VIBPA - 3-demethylubiquinone-9 3-methyltransferase OS=Vibrio parahaemolyticus GN=ubiG PE=3 SV=1 UBIG_VIBPA - Ubiquinone biosynthesis O-methyltransferase OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2...	2.0E-38	[32..310]	[3..234]
UBIG_PSEAB - Ubiquinone biosynthesis O-methyltransferase OS=Pseudomonas aeruginosa (strain UCBPP-PA14) GN=ubiG PE... gi\|107102701 - gi\|107102701\|ref\|ZP_01366619.1\| hypothetical protein PaerPA_01003767 [Pseudomonas aeruginosa PACS2] gi\|126195237, gi... - gi\|84326079\|ref\|ZP_00974109.1\| COG2227: 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol met... gi\|84319998, gi\|... - gi\|84319998\|ref\|ZP_00968384.1\| COG2227: 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol met...	9.0E-38	[34..310]	[2..230]
gi\|33576887, gi\|... - gi\|33602448\|ref\|NP_890008.1\| 3-demethylubiquinone-9 3-methyltransferase [Bordetella bronchiseptica R...	9.0E-38	[29..310]	[23..257]
tr\|E4RDT7\|E4RDT7... - 3-demethylubiquinone-9 3-methyltransferase OS=Pseudomonas putida (strain BIRD-1) GN=ubiG PE=3 SV=1 UBIG_PSEP1 - Ubiquinone biosynthesis O-methyltransferase OS=Pseudomonas putida (strain F1 / ATCC 700007) GN=ubiG ... tr\|I7C6V2\|I7C6V2... - 3-demethylubiquinone-9 3-methyltransferase OS=Pseudomonas putida (strain DOT-T1E) GN=ubiG PE=3 SV=1 UBIG_PSEPK - Ubiquinone biosynthesis O-methyltransferase OS=Pseudomonas putida (strain KT2440) GN=ubiG PE=3 SV=1	1.0E-37	[34..310]	[2..230]
UBIG_PASMU - 3-demethylubiquinone-9 3-methyltransferase OS=Pasteurella multocida GN=ubiG PE=3 SV=1 UBIG_PASMU - Ubiquinone biosynthesis O-methyltransferase OS=Pasteurella multocida (strain Pm70) GN=ubiG PE=3 SV=1	1.0E-37	[34..309]	[2..239]

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Predicted Domain #1

Region A:
Residues: [1-312]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLRSRFLKV IHVRKQLSAC SRFAIQTQTR CKSTDASEDE VKHFQELAPT WWDTDGSQRI  60
   61 LHKMNLTRLD FVQRTVRNQV KIQNPEIFVP GFNYKEFLPE YVCDNIQREM QESIETNLDK 120
  121 RPEVSVLDVG CGGGILSESL ARLKWVKNVQ GIDLTRDCIM VAKEHAKKDP MLEGKINYEC 180
  181 KALEDVTGQF DIITCMEMLE HVDMPSEILR HCWSRLNPEK GILFLSTINR DLISWFTTIF 240
  241 MGENVLKIVP KGTHHLSKYI NSKEILAWFN DNYSGQFRLL DLKGTMYLPY QGWVEHDCSD 300
  301 VGNYFMAIQR LN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	16.0
Match:	1r00A_
Description:	Crystal structure of aclacinomycin-10-hydroxylase (RdmB) in complex with S-adensyl-L-homocystein (SAH)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.25333584501255	bayes_pls_golite062009
transferase activity	1.07321114919891	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.612108481676679	bayes_pls_golite062009
methyltransferase activity	0.606225212585352	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	0.14147363365106	bayes_pls_golite062009
binding	0.109975487409217	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: