YRC Public Data Repository - Protein Structure Prediction

Protein:	SMY2
Organism:	Saccharomyces cerevisiae
Length:	740 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SMY2.

Description	E-value	Query Range	Subject Range
SMY2 - Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p su...	280.0	[0..1]	[740..51]
gi\|28564097 - gi\|28564097\|gb\|AAO32427.1\| SMY2 [Saccharomyces bayanus]	159.0	[0..1]	[684..1]
gi\|3668187 - gi\|3668187\|dbj\|BAA33452.1\| myosin heavy chain [Theragra chalcogramma]	153.0	[0..231]	[723..733]
gi\|68388302 - gi\|68388302\|ref\|XP_696268.1\| PREDICTED: similar to slow myosin heavy chain 1 [Danio rerio]	144.0	[0..236]	[716..1801]
gi\|32401139 - gi\|32401139\|gb\|AAP80764.1\| unknown [Trypanosoma cruzi]	139.0	[0..5]	[186..671]
gi\|28564888 - gi\|28564888\|gb\|AAO32528.1\| YPL105C [Saccharomyces castellii]	138.0	[0..46]	[740..13]
gi\|7549210 - gi\|7549210\|gb\|AAF63787.1\|AF142406_1 200 kDa antigen p200 [Babesia bigemina]	131.0	[0..120]	[716..43]
gi\|76643939 - gi\|76643939\|ref\|XP_872424.1\| PREDICTED: similar to myosin, heavy polypeptide 4, skeletal muscle, par...	131.0	[0..229]	[721..554]
gi\|118352773 - gi\|118352773\|ref\|XP_001009657.1\| hypothetical protein TTHERM_00155290 [Tetrahymena thermophila] gi\|118352773, gi... - gi\|89291424\|gb\|EAR89412.1\| hypothetical protein TTHERM_00155290 [Tetrahymena thermophila SB210], gi\|...	125.0	[0..190]	[721..388]

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Predicted Domain #1

Region A:
Residues: [1-178]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIAPDSQRLF GSFDEQFKDL KLDSVDTENN NTHGVSTILD SSPASVNNNT NGAVAASVNT  60
   61 VPGSTFRSNT PLLGGRHPLS RTSSLIDSIG IQRAASPFSS MKEPFIPQSS GVMSSSFWHG 120
  121 DHPESRVSTP VQQHPLLQRN ESSSSFSYAA NLGVNLSTHS LAVDITPLST PTAAQSHV

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [179-634]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLFPSSDIPP NMSMNGMSQL PAPVSVESSW RYIDTQGQIH GPFTTQMMSQ WYIGGYFAST  60
   61 LQISRLGSTP ETLGINDIFI TLGELMTKLE KYDTDPFTTF DKLHVQTTSS DSINLNLAPY 120
  121 ASGVAATGTI KATENDIFKP LTHDNIWDMD GGTTSKGVDI KLASATTISQ TDESHKQEYK 180
  181 STTMLEKGKK EKSESVAKAL LDEQEKRNRE LKRKEEARLS KKQKQKEDDL LKKQKEQKEQ 240
  241 KEKEALEAEK QKKSEKTKKD TQTQTEGFKT SKDLPSLNSS SANPAPWASK VKVNNAIETS 300
  301 IKNGVSSTGK KKGEPLGLQQ RNSKEEKQKE ELKSVLNWAN KSSLPSNQTI DIKSQFQKSP 360
  361 KGMKESSPLK ELEDPNFIEE QKKLWEKVQS SSKQVKSTSS ASTTTSSWTT VTSKGKAPIG 420
  421 TVVSPYSKTN TSLNSSLTAK TSTTSTTTTF ASMNNV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	19.154902
Match:	1i84S
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [635-740]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPRQEFIKWC KSQMKLNSGI TNNNVLELLL SLPTGPESKE LIQETIYANS DVMDGRRFAT  60
   61 EFIKRRVACE KQGDDPLSWN EALALSGNDD DGWEFQVVSK KKGRKH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.221849
Match:	2tmaA
Description:	Tropomyosin
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits