| Protein: | USP8 |
| Organism: | Homo sapiens |
| Length: | 1118 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for USP8.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..1118] | [3..1120] |
|
|
0.0 | [1..1118] | [1..1118] |
|
|
0.0 | [1..1118] | [1..1118] |
|
|
0.0 | [1..1118] | [1..1081] |
|
|
0.0 | [1..1118] | [29..1108] |
|
Region A: Residues: [1-144] |
1 11 21 31 41 51
| | | | | |
1 MPAVASVPKE LYLSSSLKDL NKKTEVKPEK ISTKSYVHSA LKIFKTAEEC RLDRDEERAY 60
61 VLYMKYVTVY NLIKKRPDFK QQQDYFHSIL GPGNIKKAVE EAERLSESLK LRYEEAEVRK 120
121 KLEEKDRQEE AQRLQQKRQE TGRE
|
| Detection Method: |  |
| Confidence: | 11.522879 |
| Match: | 2a9uA |
| Description: | Structure of the N-terminal domain of Human Ubiquitin carboxyl-terminal hydrolase 8 (USP8) |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [145-314] |
1 11 21 31 41 51
| | | | | |
1 DGGTLAKGSL ENVLDSKDKT QKSNGEKNEK CETKEKGAIT AKELYTMMTD KNISLIIMDA 60
61 RRMQDYQDSC ILHSLSVPEE AISPGVTASW IEAHLPDDSK DTWKKRGNVE YVVLLDWFSS 120
121 AKDLQIGTTL RSLKDALFKW ESKTVLRNEP LVLEGGYENW LLCYPQYTTN
|
| Detection Method: | |
| Confidence: | 4.23 |
| Match: | 1whbA |
| Description: | Solution structure of the Rhodanese-like domain in human ubiquitin specific protease 8 (UBP8) |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| binding | 1.7573477158791 | bayes_pls_golite062009 |
| protein tyrosine phosphatase activity | 0.711045884031031 | bayes_pls_golite062009 |
| catalytic activity | 0.660280721417663 | bayes_pls_golite062009 |
| phosphoprotein phosphatase activity | 0.514129714366787 | bayes_pls_golite062009 |
| protein binding | 0.512164575740487 | bayes_pls_golite062009 |
| transferase activity | 0.24413644201982 | bayes_pls_golite062009 |
| phosphatase activity | 0.0126182055752568 | bayes_pls_golite062009 |
|
Region A: Residues: [315-530] |
1 11 21 31 41 51
| | | | | |
1 AKVTPPPRRQ NEEVSISLDF TYPSLEESIP SKPAAQTPPA SIEVDENIEL ISGQNERMGP 60
61 LNISTPVEPV AASKSDVSPI IQPVPSIKNV PQIDRTKKPA VKLPEEHRIK SESTNHEQQS 120
121 PQSGKVIPDR STKPVVFSPT LMLTDEEKAR IHAETALLME KNKQEKELRE RQQEEQKEKL 180
181 RKEEQEQKAK KKQEAEENEI TEKQQKAKEE MEKKES
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
|
Region A: Residues: [531-718] |
1 11 21 31 41 51
| | | | | |
1 EQAKKEDKET SAKRGKEITG VKRQSKSEHE TSDAKKSVED RGKRCPTPEI QKKSTGDVPH 60
61 TSVTGDSGSG KPFKIKGQPE SGILRTGTFR EDTDDTERNK AQREPLTRAR SEEMGRIVPG 120
121 LPSGWAKFLD PITGTFRYYH SPTNTVHMYP PEMAPSSAPP STPPTHKAKP QIPAERDREP 180
181 SKLKRSYS
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
|
Region A: Residues: [719-1118] |
1 11 21 31 41 51
| | | | | |
1 SPDITQAIQE EEKRKPTVTP TVNRENKPTC YPKAEISRLS ASQIRNLNPV FGGSGPALTG 60
61 LRNLGNTCYM NSILQCLCNA PHLADYFNRN CYQDDINRSN LLGHKGEVAE EFGIIMKALW 120
121 TGQYRYISPK DFKITIGKIN DQFAGYSQQD SQELLLFLMD GLHEDLNKAD NRKRYKEENN 180
181 DHLDDFKAAE HAWQKHKQLN ESIIVALFQG QFKSTVQCLT CHKKSRTFEA FMYLSLPLAS 240
241 TSKCTLQDCL RLFSKEEKLT DNNRFYCSHC RARRDSLKKI EIWKLPPVLL VHLKRFSYDG 300
301 RWKQKLQTSV DFPLENLDLS QYVIGPKNNL KKYNLFSVSN HYGGLDGGHY TAYCKNAARQ 360
361 RWFKFDDHEV SDISVSSVKS SAAYILFYTS LGPRVTDVAT
|
| Detection Method: | |
| Confidence: | 117.0 |
| Match: | 2gfoA |
| Description: | No description for 2gfoA was found. |
