YRC Public Data Repository - Protein Structure Prediction

Protein:	QCR2
Organism:	Saccharomyces cerevisiae
Length:	368 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for QCR2.

Description	E-value	Query Range	Subject Range
MPPB_MOUSE - Mitochondrial-processing peptidase subunit beta OS=Mus musculus GN=Pmpcb PE=1 SV=1	0.0	[1..368]	[52..480]
gi\|397699 - gi\|397699\|dbj\|BAA03007.1\| mitochondrial processing protease [Rattus norvegicus]	2.0E-99	[1..368]	[50..478]
gi\|3342006, gi\|4... - gi\|4758734\|ref\|NP_004270.1\| peptidase (mitochondrial processing) beta [Homo sapiens], gi\|3342006\|gb\|...	4.0E-99	[1..368]	[52..480]
gi\|195570810, gi... - gi\|195570810\|ref\|XP_002103397.1\| GD18983 [Drosophila simulans], gi\|194199324\|gb\|EDX12900.1\| GD18983 ... gi\|220945206, gi... - gi\|220955020\|gb\|ACL90053.1\| CG3731-PA [synthetic construct], gi\|220945206\|gb\|ACL85146.1\| CG3731-PA [... gi\|195328891, gi... - gi\|195328891\|ref\|XP_002031145.1\| GM24191 [Drosophila sechellia], gi\|194120088\|gb\|EDW42131.1\| GM24191... CG3731-PB, CG3731-PA - This gene is referred to in FlyBase by the symbol Dmel\CG3731 (CG3731, FBgn0038271). It is a protein...	5.0E-98	[1..368]	[35..461]
gi\|12802327 - gi\|12802327\|gb\|AAK07827.1\|AF297643_1 mitochondrial processing peptidase beta subunit [Cucumis melo]	6.0E-89	[1..366]	[88..517]
gi\|587566 - gi\|587566\|emb\|CAA56521.1\| mitochondrial processing peptidase [Solanum tuberosum]	3.0E-88	[1..366]	[93..523]
gi\|3659967, gi\|5... - gi\|5822457\|pdb\|2BCC\|A Chain A, Stigmatellin-Bound Cytochrome Bc1 Complex From Chicken, gi\|3660376\|pd...	8.0E-88	[3..368]	[10..437]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	9.0E-88	[1..366]	[93..523]

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Predicted Domain #1

Region A:
Residues: [1-133]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSAARLQFA QGSVRRLTVS ARDAPTKIST LAVKVHGGSR YATKDGVAHL LNRFNFQNTN  60
   61 TRSALKLVRE SELLGGTFKS TLDREYITLK ATFLKDDLPY YVNALADVLY KTAFKPHELT 120
  121 ESVLPAARYD YAV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [158-217]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLLYDGVERV SLQDIKDFAD KVYTKENLEV SGENVVEADL KRFVDESLLS TLPAGKSLVS  60
   61

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10060.0
Match:	1ezvB_
Description:	Cytochrome bc1 core subunit 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ubiquinol-cytochrome-c reductase activity	10.0305725791312	bayes_pls_golite062009
oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	10.0305725791312	bayes_pls_golite062009
oxidoreductase activity, acting on diphenols and related substances as donors	6.64269017601856	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	4.17510847735476	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	4.03221088799464	bayes_pls_golite062009
oxidoreductase activity	3.89224384280888	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	3.48526983761385	bayes_pls_golite062009
cation transmembrane transporter activity	3.30443970063928	bayes_pls_golite062009
ion transmembrane transporter activity	3.14174223148448	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.79848305609896	bayes_pls_golite062009
substrate-specific transporter activity	2.6563825341516	bayes_pls_golite062009
binding	1.92389577633668	bayes_pls_golite062009
catalytic activity	1.30647052031202	bayes_pls_golite062009
protein binding	1.16040346226904	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [134-157]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEQCPVKSAE DQLYAITFRK GLGN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [218-368]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSEPKFFLGE ENRVRFIGDS VAAIGIPVNK ASLAQYEVLA NYLTSALSEL SGLISSAKLD  60
   61 KFTDGGLFTL FVRDQDSAVV SSNIKKIVAD LKKGKDLSPA INYTKLKNAV QNESVSSPIE 120
  121 LNFDAVKDFK LGKFNYVAVG DVSNLPYLDE L

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10060.0
Match:	1ezvB_
Description:	Cytochrome bc1 core subunit 2
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: