YRC Public Data Repository - Protein Structure Prediction

Protein:	ORC4
Organism:	Saccharomyces cerevisiae
Length:	529 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ORC4.

Description	E-value	Query Range	Subject Range
gi\|151942934 - gi\|151942934\|gb\|EDN61280.1\| origin recognition complex (ORC) subunit [Saccharomyces cerevisiae YJM78... ORC4_YEAST - Origin recognition complex subunit 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ORC... ORC4 - Subunit of the origin recognition complex, which directs DNA replication by binding to replication o... gi\|190408086 - gi\|190408086\|gb\|EDV11351.1\| origin recognition complex 56 kDa subunit [Saccharomyces cerevisiae RM11...	5.0E-99	[1..529]	[1..529]
CDC6_PYRHO - (O57864) Cell division control protein 6 homolog (CDC6 homolog) gi\|14590068, gi\|... - gi\|3256510\|dbj\|BAA29193.1\| 437aa long hypothetical protein [Pyrococcus horikoshii OT3], gi\|14590068\|...	5.0E-72	[22..487]	[1..426]
gi\|5457555, gi\|1... - gi\|5457555\|emb\|CAB49046.1\| Cdc6/orc1 cell division control protein 6 [Pyrococcus abyssi GE5], gi\|145... CDC6_PYRAB - (Q9V2F2) Cell division control protein 6 homolog (CDC6 homolog)	8.0E-71	[30..486]	[4..420]
gi\|20088900, gi\|... - gi\|20088900\|ref\|NP_614975.1\| cell division control protein 6 [Methanosarcina acetivorans C2A], gi\|19...	1.0E-67	[41..496]	[9..418]
CD61_METAC, CDC6... - Cell division control protein 6 homolog 1 OS=Methanosarcina acetivorans GN=cdc6-1 PE=3 SV=2, (Q8TUR2... CDC61_METAC - ORC1-type DNA replication protein 1 OS=Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JC...	2.0E-67	[41..496]	[3..412]
CDC6_PYRFU - Cell division control protein 6 homolog OS=Pyrococcus furiosus GN=cdc6 PE=3 SV=1 CDC6_PYRFU - ORC1-type DNA replication protein OS=Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / ...	4.0E-67	[48..486]	[10..408]
CD61_METMA, CDC6... - Cell division control protein 6 homolog 1 OS=Methanosarcina mazei GN=cdc6-1 PE=3 SV=1, (Q8PXA8) Cell... CDC61_METMA - ORC1-type DNA replication protein 1 OS=Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 /...	1.0E-66	[41..496]	[3..412]
gi\|186464265, gi... - gi\|23123765\|ref\|ZP_00105811.1\| COG0465: ATP-dependent Zn proteases [Nostoc punctiforme PCC 73102], g...	1.0E-65	[40..410]	[146..472]
ORC4_MOUSE - Origin recognition complex subunit 4 OS=Mus musculus GN=Orc4 PE=1 SV=2	2.0E-65	[47..505]	[13..426]
gi\|17231134, gi\|... - gi\|17231134\|ref\|NP_487682.1\| cell division protein [Nostoc sp. PCC 7120], gi\|17132775\|dbj\|BAB75341.1... gi\|25308078 - pir\|\|AC2261 cell division protein [imported] - Nostoc sp. (strain PCC 7120)	2.0E-65	[40..410]	[146..472]

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Predicted Domain #1

Region A:
Residues: [1-278]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTISEARLSP QVNLLPIKRH SNEEVEETAA ILKKRTIDNE KCKDSDPGFG SLQRRLLQQL  60
   61 YGTLPTDEKI IFTYLQDCQQ EIDRIIKQSI IQKESHSVIL VGPRQSYKTY LLDYELSLLQ 120
  121 QSYKEQFITI RLNGFIHSEQ TAINGIATQL EQQLQKIHGS EEKIDDTSLE TISSGSLTEV 180
  181 FEKILLLLDS TTKTRNEDSG EVDRESITKI TVVFIFDEID TFAGPVRQTL LYNLFDMVEH 240
  241 SRVPVCIFGC TTKLNILEYL EKRVKSRFSQ RVIYMPQI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	54.30103
Match:	1lv7A_
Description:	AAA domain of cell division protein FtsH
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [279-371]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QNLDDMVDAV RNLLTVRSEI SPWVSQWNET LEKELSDPRS NLNRHIRMNF ETFRSLPTLK  60
   61 NSIIPLVATS KNFGSLCTAI KSCSFLDIYN KNQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	54.30103
Match:	1lv7A_
Description:	AAA domain of cell division protein FtsH
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [372-529]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSNNLTGRLQ SLSDLELAIL ISAARVALRA KDGSFNFNLA YAEYEKMIKA INSRIPTVAP  60
   61 TTNVGTGQST FSIDNTIKLW LKKDVKNVWE NLVQLDFFTE KSAVGLRDNA TAAFYASNYQ 120
  121 FQGTMIPFDL RSYQMQIILQ ELRRIIPKSN MYYSWTQL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits